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Dopant cartridge and method for stably controlling concentration of ion mobility spectrometry chemical dopant

An ion mobility spectrometry and chemical doping technology is applied in the field of dopant cartridges for stably controlling the concentration of chemical dopants in a positive ion high pressure mode, which can solve the problems of large consumption of acetone, troublesome on-site application of experimental operators, etc. Effects of ionization, signal enhancement, extended life cycle

Inactive Publication Date: 2020-12-11
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, with the wide application of photoionization ion mobility spectrometry in recent years, it is found that the consumption of acetone is very large; and in the actual use process, the impurities contained in the reagent after the dopant is used up often trouble the field application of the experimental operator

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  • Dopant cartridge and method for stably controlling concentration of ion mobility spectrometry chemical dopant
  • Dopant cartridge and method for stably controlling concentration of ion mobility spectrometry chemical dopant
  • Dopant cartridge and method for stably controlling concentration of ion mobility spectrometry chemical dopant

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Embodiment 1

[0031] Connect the apparatus according to the above-mentioned embodiment, the inner diameter of the tetrafluoro hollow tube on the upper cover of the reagent bottle in the dopant cylinder is an inner diameter of 250 μm, and a length of 1 cm, and the doping reagent of acetone and carbon tetrachloride is housed in the doping reagent bottle, wherein 0.2 Mix 1 ml carbon tetrachloride and 2 ml acetone, and the steam diffuses from the tetrafluoro hollow tube to the outside of the doping reagent bottle and the dopant cylinder. Use the combination of acetone and carbon tetrachloride as the doping reagent to ionize to generate reagent ions. When the doping reagent generally reaches 1000mv according to the daily required RIP signal strength, use 2ml of acetone and 0.2ml of carbon tetrachloride as the doping reagent. Acetone basically If it is used up for more than ten days, the combined dopant reagent ion peak is as follows image 3 mentioned.

[0032] Can find out by the result of com...

Embodiment 2

[0034] In the prior art, sensors are used to identify the liquid level control of reagents. Since the composition of the doping reagent is usually an organic phase, and the bottle of the doping reagent is relatively small, it is not suitable for adding a sensor warning light node for the doping reagent. Current photoionization ion mobility spectrometry uses dopant reagent-depleted nodes, often by doping reagents with light-free reagent ion peak identification. This method uses a combination of acetone and carbon tetrachloride as a doping reagent. When the concentration of acetone is very low, there will be peak tailing, which can be identified by the half-peak width of the ion mobility spectrum. Such as image 3 , under the same conditions, the normal spectral peak width at half maximum is 0.24~0.32ms; if Figure 4 As stated, the half-peak width is 0.48ms, which is already greater than 0.4ms, which means that the acetone is about to be exhausted (there is still a surplus), a...

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Abstract

The invention discloses a method for stably controlling the concentration of an ion mobility spectrometry chemical dopant. According to the invention, the method comprises the steps: employing a photoionization ion mobility spectrometry technology as a basic detection technology; in a positive ion high-voltage mode, optimizing the types of dopants, employing a combined adding mode of mixed dopants, and then selecting a dopant control mode to effectively control the release concentration of the dopant. therefore, signals can be remarkably enhanced under the low-concentration condition of dopan,the service life of dopan can be effectively prolonged, and meanwhile, nodes needing to be replaced by reagents are judged by utilizing peak pattern changes caused by reagent concentration changes; according to the method, high signal intensity under the low-concentration condition of dopant can be realized, and the detection sensitivity of a target sample can be improved.

Description

technical field [0001] The invention belongs to the technical field of photoionization ion mobility spectrometry, and in particular relates to a dopant cartridge and a method for stably controlling the concentration of a chemical dopant in a positive ion high-voltage mode. Background technique [0002] Ion Mobility Spectrometry (IMS) technology is a rapid separation and detection technology that appeared in the 1970s. Compared with traditional mass spectrometry and chromatography instruments, it has the characteristics of simple structure, high sensitivity, fast analysis speed and reliable results. Ionization sources for ion mobility spectrometry include radioactive ionization sources, corona discharge ionization sources, photoionization sources, and electrospray ionization sources. The generation of gas-phase ions in ion mobility spectrometry is a prerequisite for separation and detection. The ionization source that converts analytes from neutral molecules into analyte ions...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/16H01J49/00B01L3/00G01N27/62
CPCB01L3/508G01N27/622H01J49/0027H01J49/161
Inventor 王新李海洋肖瑶厉梅
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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