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Method for simultaneously preparing CBG, CBDV, CBD and THCV from industrial hemp

An industrial hemp and industrial technology, applied in the field of extraction and separation of natural phytochemical components, can solve the problems of waste of resources, repeated investment, etc., and achieve the effects of high recovery rate, high investment benefit, and reducing solvent residues

Pending Publication Date: 2020-12-11
滇麻生物科技(曲靖)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, at present, only two kinds of CBG, CBDV, CBD, and THCV can be prepared at the same time. The different conditions in the preparation process lead to the preparation of one or two components, and the other components are used as waste and THC (THC) are destroyed together, resulting in a waste of resources, and such a process also has the risk of repeated investment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The method for simultaneously preparing CBG, CBDV, CBD, THCV from industrial hemp described in the present embodiment 1 comprises the following steps:

[0026] ① Raw material crushing: crush the flowers and leaves of industrial hemp into flowers and leaves powder, and the particle size of flowers and leaves powder is 40 mesh;

[0027] ②Drying: Baking the flower and leaf powder obtained by pulverizing in step ①, the baking temperature is 130°C, and baking until the weight loss is more than 7%;

[0028] ③Extraction: Feed the leaf powder baked in step ② and ethanol at a solid-to-liquid ratio of 1:12, and the mass concentration of ethanol is 80%; then extract at a temperature of 18°C ​​for 1.5h, after the extraction is completed Concentrate at a pressure of 0.04Mpa and a temperature of 50°C until the specific gravity is 0.94, and then freeze the concentrate at -20°C for 1 hour;

[0029] ④ Filtration: Filter the concentrated liquid after freezing in step ③, and use a 500-me...

Embodiment 2

[0035] The method for simultaneously preparing CBG, CBDV, CBD, THCV from industrial hemp described in this embodiment 2 comprises the following steps:

[0036] ① Raw material crushing: crush the flowers and leaves of industrial hemp into flowers and leaves powder, and the particle size of flowers and leaves powder is 25 mesh;

[0037] ②Drying: Baking the flower and leaf powder obtained by pulverizing in step ①, the baking temperature is 120°C, and baking until the weight loss is more than 7%;

[0038] ③Extraction: Feed the leaf powder baked in step ② and ethanol at a solid-to-liquid ratio of 1:10, and the mass concentration of ethanol is 82.5%; then extract at a temperature of 25°C for 13 hours, and after the extraction is completed, in Concentrate at a pressure of 0.06Mpa and a temperature of 60°C until the specific gravity is 0.945, then freeze the concentrate at -30°C for 2 hours;

[0039] ④ Filtration: Filter the concentrated liquid after freezing in step ③, and use a 550...

Embodiment 3

[0045] The method for simultaneously preparing CBG, CBDV, CBD, THCV from industrial hemp described in this embodiment 3 comprises the following steps:

[0046] ① Raw material crushing: crush the flowers and leaves of industrial hemp into flowers and leaves powder, and the particle size of flowers and leaves powder is 40 mesh;

[0047] ②Drying: Baking the flower and leaf powder obtained by pulverizing in step ①, the baking temperature is 130°C, and baking until the weight loss is more than 7%;

[0048] ③Extraction: Feed the leaf powder baked in step ② and ethanol at a solid-to-liquid ratio of 1:12, and the mass concentration of ethanol is 85%; then extract at a temperature of 28°C for 4 hours, and after the extraction is completed, in Concentrate at a pressure of 0.07Mpa and a temperature of 70°C until the specific gravity is 0.95, then freeze the concentrate at -40°C for 3 hours;

[0049] ④ Filtration: Filter the concentrated liquid after step ③ freezing, and use a 600-mesh f...

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Abstract

The invention discloses a method for simultaneously preparing CBG, CBDV, CBD and THCV from industrial hemp. The method comprises the following steps of: (1) raw material crushing; (2) drying; (3) extraction: extracting, concentrating and freezing baked floral leaf powder and ethanol according to a solid-to-liquid ratio of 1: (8-12); (4) filtering: filtering the frozen concentrated solution, and extracting to obtain a hemp extract; (5) molecular distillation: carrying out molecular distillation on the hemp extract for three times; (6) chromatographic column separation: dissolving CBG, CBDV, CBDand THCV oil obtained by distillation with ethanol with the mass concentration of 60%, and then loading a sample by a wet method for chromatographic column separation; and (8) recrystallization: respectively dissolving the prepared CBG crystal, CBDV crystal, CBD crystal and THCV oil with ethanol, recrystallizing, washing and drying to obtain the finished products CBG crystal, CBDV crystal, CBD crystal and THCV crystal. The raw materials and reagents used in the method are cheap, easy to obtain and low in cost, the adopted operation and method are simple and easy to implement, and the preparedproduct is high in purity and good in safety.

Description

technical field [0001] The invention belongs to the technical field of extraction and separation of natural phytochemical components, and in particular relates to a method for simultaneously preparing CBG, CBDV, CBD and THCV from industrial hemp. Background technique [0002] Industrial hemp refers to hemp that has been legally grown and contains less than 0.3% tetrahydrocannabinol (THC). At present, it has been legally grown and processed in Yunnan and Heilongjiang. In recent years, industrial hemp has attracted more and more attention, and a large number of large health industries have deployed industrial hemp. The most valuable components in industrial hemp are mainly cannabigerol (CBG), cannabidiol (CBDV), cannabidiol (CBD) and tetrahydrocannabinol THCV. [0003] Currently, a growing number of anecdotal reports from patients and physicians highlight the potential of CBD as a treatment for a variety of diseases, ① autoimmune diseases (inflammation, rheumatoid arthritis);...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C37/82C07C37/74C07C37/84C07C39/19C07C39/23C07D311/80
CPCC07C37/004C07C37/82C07C37/74C07C37/84C07D311/80C07C2601/16C07C39/19C07C39/23
Inventor 尹升权唐瑛高建慎杨成周李登峰张岚燕
Owner 滇麻生物科技(曲靖)有限公司
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