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Traditional Chinese medicine composition for treating Alzheimer's disease as well as extraction method and application thereof

A technology for Alzheimer's disease and a composition, which is applied in the field of medicine and achieves the effects of strong adsorption capacity, high purity and improved dissolution effect

Inactive Publication Date: 2020-12-11
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing main hypothesis is that the excessive accumulation of amyloid β plaques in the pathogenesis of AD, and the hyperphosphorylation of Tau protein to produce neurofibrillary tangles mediate the final pathogenesis process. Explain many problems in the pathogenesis of AD

Method used

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  • Traditional Chinese medicine composition for treating Alzheimer's disease as well as extraction method and application thereof
  • Traditional Chinese medicine composition for treating Alzheimer's disease as well as extraction method and application thereof
  • Traditional Chinese medicine composition for treating Alzheimer's disease as well as extraction method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 1 group screening:

[0034] PC12 induced by sodium azide by determining the extracts of 11 medicinal materials such as ginseng, American ginseng, epimedium, pinnatifida, sapindus, white peony root, rhodiola rosea, acanthopanax, jujube seed, schisandra, and saffron. In order to preliminarily evaluate the pharmacological effects of these 11 medicinal materials.

[0035] The preparation method of the water extract of 11 medicinal materials is as follows:

[0036] Weigh 50g each of ginseng, American ginseng, epimedium, campanula, sapindus, white peony root, rhodiola rosea, acanthopanax, jujube seed, schisandra, saffron and other 11 medicinal materials, crush them, and pass through 80 meshes Sieve, weigh 10g of each medicinal material, add pure water to reflux and extract 3 times, each time for 1.5h, the amount of water added each time is 100ml, combine the filtrate, count as raw medicinal material, concentrate to 200mg / ml, and use the medicinal liquid before use The cultu...

Embodiment 2

[0081] A preparation method of a Chinese medicine composition for treating senile dementia, comprising the following steps:

[0082] S01 Take 50g of dried ginseng, 100g of Acanthopanax and 50g of American ginseng, respectively pulverize, sieve and mix to obtain a mixed powder, place the mixed powder on a steamer and cook for 30 minutes, then add Pure water, after soaking for 1 hour, reflux extraction once, the extraction time is 1.5h, the amount of pure water added each time is equivalent to 20 times the total weight of the mixed powder, combined extracts, filtered, concentrated to the equivalent of the total weight of the mixed powder 0.5 times of the concentration, add ethanol for alcohol precipitation, the amount of ethanol added is 20 times of the total weight of the concentrated solution, filter to obtain the supernatant, the supernatant is concentrated until it has no alcohol smell, calculated based on the total weight of the mixed powder, and then add pure water Dilute ...

Embodiment 3

[0086] A preparation method of a Chinese medicine composition for treating senile dementia, comprising the following steps:

[0087] S01 Take 50g of dried ginseng, 100g of Acanthopanax and 50g of American ginseng, respectively pulverize, sieve and mix to obtain a mixed powder, place the mixed powder on a steamer and cook for 30 minutes, then add Pure water, after soaking for 1 hour, reflux extraction twice, each extraction time is 1.5h, the amount of pure water added each time is equivalent to 10 times the total weight of the mixed powder, combined extracts, filtered, concentrated to the equivalent of mixed powder 1 times the total weight, add ethanol for alcohol precipitation, the amount of ethanol added is 50 times the total weight of the concentrated solution, filter to obtain a supernatant, the supernatant is concentrated until it has no alcohol smell, calculated based on the total weight of the mixed powder, and then added Dilute with pure water to 0.5g / mL to obtain a dil...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating the Alzheimer's disease. According to the invention, four medicinal materials, namely radix ginseng, fructus schisandrae, radix acanthopanacis semticosi and American ginseng, with remarkable sodium azide-induced PC12 cell injury resistance are screened out from 11 medicinal materials, and the radix ginseng, the fructusschisandrae, the radix acanthopanacis semticosi and the American ginseng form a compound; the mass ratio of the radix ginseng, the fructus schisandrae, the radix acanthopanacis semticosi and the American ginseng in the compound is (1-10): (1-10): (2-10): (0.5-8); pharmacological and pharmacodynamic experiments prove that the traditional Chinese medicine composition disclosed by the invention hasa remarkable effect on treating the Alzheimer's disease and can be used for preventing and treating the Alzheimer's disease; and the preparation method of the traditional Chinese medicine compositionfor treating the Alzheimer's disease is simple in process, beneficial to large-scale industrial production operation and small in pollution.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a traditional Chinese medicine composition for treating senile dementia and its extraction method and application. Background technique [0002] Alzheimer's disease (AD) patients will experience symptoms such as memory loss, behavioral impairment, aphasia, apraxia, and decreased ability to live. The long-term course of the disease brings a heavy burden on the patients themselves, their families and society. According to epidemiological research statistics, it is estimated that there will be 130-150 million Alzheimer's patients in the world in 2050. All clinical trials of new drug research aimed at abnormal deposition of Aβ have failed. Therefore, up to now, there is no medicine for completely curing the disease, and the few existing medicines for improving the clinical symptoms of AD have many adverse reactions. Although the clinical drugs represented by donepezil are effective, they o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/79A61K36/57A61P25/28
CPCA61K36/254A61K36/258A61K36/57A61K36/79A61K2236/19A61K2236/331A61K2236/55A61P25/28A61K2300/00
Inventor 杨波徐艳明孙慧峰张宁耿放王发善
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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