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Application of substance for detecting HLA-A*30:01 allele in evaluating risk of severe drug rash caused by levofloxacin

A technology of levofloxacin and HLA-A, applied in the field of biomedicine

Active Publication Date: 2020-12-04
FUDAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is how to detect or evaluate the risk of adverse drug reactions in people responding to levofloxacin

Method used

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  • Application of substance for detecting HLA-A*30:01 allele in evaluating risk of severe drug rash caused by levofloxacin
  • Application of substance for detecting HLA-A*30:01 allele in evaluating risk of severe drug rash caused by levofloxacin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1, HLA-A*30:01 allele is a risk genetic marker of levofloxacin-induced severe drug eruption

[0046] 1. Sample

[0047] 1. Case samples (severe drug eruption group caused by levofloxacin)

[0048] The case samples in this example were 11 patients with severe drug eruption caused by levofloxacin from Huashan Hospital Affiliated to Fudan University in Shanghai, China. These 11 patients received levofloxacin for pulmonary infection, urinary tract infection or other infections. Among the 11 patients, there were 8 males and 3 females, with an average age of 47 years. The time from the start of levofloxacin to the appearance of severe drug eruption symptoms ranged from 1 day to 21 days (average 7.9 days). The 11 patients included 4 SJS, 4 TEN, 1 SJS / TEN overlap, 1 DRESS, and 1 AGEP. The diagnosis of severe drug eruption is based on the patient's medical history, clinical manifestations and laboratory tests.

[0049] 2. Normal control samples (normal population co...

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Abstract

The invention discloses an application of a substance for detecting an HLA-A*30:01 allele in evaluating the risk of human severe drug rash caused by levofloxacin. The invention also discloses an application of the substance for detecting the HLA-A*30:01 allele in preparation of a product for detecting or evaluating the risk of human adverse drug reaction responding to the levofloxacin. Experimentsprove that the human leukocyte antigen gene-HLA-A*30:01 allele is related to the risk of the severe drug rash caused by the levofloxacin. The HLA-A*30:01 allele can be used as a marker gene for predicting the occurrence risk of the severe drug rash caused by the levofloxacin.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to the application of substances for detecting HLA-A*30:01 alleles in evaluating the risk of severe drug eruption caused by levofloxacin. Background technique [0002] The human leucocyte antigen (HLA) gene system is the human major histocompatibility complex (MHC), which is located on the short arm of chromosome 6 and is composed of a series of closely linked gene loci A genetic complex with a high degree of polymorphism. Its encoded product is leukocyte antigen, which is involved in antigen processing and presentation, and plays an important role in specific immune response and immune regulation. In addition, HLA molecules are also involved in the occurrence of transplant rejection and various pathological processes. [0003] Levofloxacin (Levofloxacin), chemical name ((S)-(-)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7- Oxo-7H-pyrido[1,2,3-de]-[1...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883C12Q1/6881
CPCC12Q1/6883C12Q1/6881C12Q2600/106C12Q2600/156Y02A50/30
Inventor 邢清和骆肖群杨凡萍
Owner FUDAN UNIV
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