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Refining process of oligomeric dextran and production process prediction method

A technology of dextran and process, which is applied in the field of refining process and production process prediction of oligomeric dextran, and can solve problems such as difficult to achieve oligosaccharide retention rate

Active Publication Date: 2020-12-04
NANJING UNIV OF TECH
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Problems solved by technology

In practice, it is difficult to achieve 100% rejection of target oligosaccharides with a certain molecular weight distribution during diafiltration

Method used

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  • Refining process of oligomeric dextran and production process prediction method
  • Refining process of oligomeric dextran and production process prediction method
  • Refining process of oligomeric dextran and production process prediction method

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Embodiment Construction

[0050] Due to the prebiotic properties of oligosaccharides and their role in healthcare, it is urgent to separate and purify oligosaccharides from complex solutions. The present invention systematically studies the diafiltration process of oligomeric dextran refining, and then extends the theoretical model. Using intermittent feed diafiltration, through the small pore size ZrO with narrow pore size distribution 2Ceramic ultrafiltration membrane narrows the molecular weight distribution of oligodextran. The production efficiency is involved in the intermittent diafiltration process. Under different diafiltration operations, the production efficiency varies greatly. It is particularly important to establish a batch diafiltration model to realize the prediction and optimization of the membrane process. Based on mass balance and concentration polarization models, a model considering the variation of solute rejection with concentration was developed to describe the process. The m...

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Abstract

The invention relates to a refining process of oligomeric dextran and a production process prediction method of oligomeric dextran, and belongs to the technical field of membrane separation. On one hand, aiming at glucan oligosaccharide (with the molecular weight of 5-8 kDa), a small-aperture ZrO2 ceramic ultrafiltration membrane is adopted, and dextran with relatively low molecular weight is removed through intermittent percolation, so that the molecular weight distribution of the glucan oligosaccharide is narrowed,on the other hand, a novel percolation model is provided by considering the changed solute retention rate. The model can be used to achieve prediction of the percolation process and optimization of the percolation process by maximizing productivity.

Description

technical field [0001] The invention relates to a refining process of oligomeric dextran and a production process prediction method, belonging to the technical field of membrane separation. Background technique [0002] Oligodextran (molecular weight 5-8kDa) is a typical functional oligosaccharide, which has good water solubility, colloidal properties and biocompatibility, can expand blood volume, and prepare iron preparations for the treatment of anemia, but in clinical Excessive molecular weight distribution of oligodextran in application will cause clinical side effects, so the purification of oligodextran is very important. [Patent Document 1] proposed a scheme to obtain dextran with different molecular weight levels by using two-stage membrane separation, but in this technology, membranes with different pore sizes need to be used to separate dextran, and the separation accuracy is not high, and the separation effect is not easy The problem of control. [0003] From an...

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Application Information

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IPC IPC(8): C08B37/02
CPCC08B37/0021C08B37/0003
Inventor 范益群陈献富齐婷邱鸣慧
Owner NANJING UNIV OF TECH
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