Supercritical particle preparation process of grease

A preparation process and supercritical technology, which is applied in the direction of liquid separation into beads and granulation, can solve the problems of low surface oil rate, achieve high embedding rate, less wall material consumption, and solve the effect of clogging

Pending Publication Date: 2020-12-01
胡勇刚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In order to solve the technical problems existing in the background technology, the present invention proposes a preparation process of supercritical particles of grease. In the present invention, the grease is wrapped in the wall material under the condition of low temperature and oxygen-free, which can keep the active ingredients in the grease from being easily absorbed. Oxidation significantly improves the quality stability of the oil and greatly expands the scope of application of the original easy-to-oxidize oil. In the supercritical emulsification process, the amount of wall material is small, with good embedding efficiency and lower surface oil rate. At the same time, the nozzle monitors the drug blockage through the pressure sensor, and uses the heating jacket to raise the temperature to solve the problem of drug blockage

Method used

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Examples

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Effect test

Embodiment 1

[0035] Mix 10 g of gum arabic and 3 g of sodium alginate and infuse with CO 2 In the fluid reaction kettle, add Tween 80 and linseed oil, and cover it. Open CO 2 The cylinder is pressurized by a high-pressure pump and enters the fluid reactor. 50mL of purified water in the storage tank was injected into the reaction kettle at a speed of 5mL / min. Adjust the pre-expansion pressure to 5MPa, the pre-expansion temperature to 38K, and the magnetic stirring power to 20MPa, and stir for 30 minutes until the microemulsion is fully formed. Then set the pressure of the collection tank to be 5MPa, the temperature to be 298K, and control the supercritical CO 2 Precipitation conditions, rapid release of pressure, the formed microemulsion with CO 2 Spray into the collection tank through the nozzle at a flow rate of 2L / min, so that the grease particles are evenly dispersed in the water phase medium. After the injection process is over, keep the pressure and continue to feed CO into the c...

Embodiment 2

[0037] Mix 10 g of gum arabic and 3 g of sodium alginate and infuse with CO 2 In the fluid reaction kettle, add Tween 80 and linseed oil, and cover it. Open CO 2 The cylinder is pressurized by a high-pressure pump and enters the fluid reactor. 50mL of purified water in the storage tank was injected into the reaction kettle at a speed of 5mL / min. Adjust the pre-expansion pressure to 10MPa, the pre-expansion temperature to 38K, and the magnetic stirring power to 20MPa, and stir for 30 minutes until the microemulsion is fully formed. Then set the pressure of the collection tank to be 5MPa, the temperature to be 298K, and control the supercritical CO 2 Precipitation conditions, rapid release of pressure, the formed microemulsion with CO 2 Spray into the collection tank through the nozzle at a flow rate of 2L / min, so that the grease particles are evenly dispersed in the water phase medium. After the injection process is over, keep the pressure and continue to feed CO into the ...

Embodiment 3

[0039] Mix 10 g of gum arabic and 3 g of sodium alginate and infuse with CO 2 In the fluid reaction kettle, add Tween 80 and linseed oil, and cover it. Open CO 2 The cylinder is pressurized by a high-pressure pump and enters the fluid reactor. 50mL of purified water in the storage tank was injected into the reaction kettle at a speed of 5mL / min. Adjust the pre-expansion pressure to 15MPa, the pre-expansion temperature to 38K, and the magnetic stirring power to 20MPa, and stir for 30 minutes until the microemulsion is fully formed. Then set the pressure of the collection tank to be 5MPa, the temperature to be 298K, and control the supercritical CO 2 Precipitation conditions, rapid release of pressure, the formed microemulsion with CO 2 Spray into the collection tank through the nozzle at a flow rate of 2L / min, so that the grease particles are evenly dispersed in the water phase medium. After the injection process is over, keep the pressure and continue to feed CO into the ...

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Abstract

The invention relates to a supercritical particle preparation process of grease. The process comprises the following steps: dissolving a wall material, grease and an emulsifier in fluid CO2 in a supercritical state to form a supercritical microemulsion; and after expanding at a certain stirring speed, a certain pressure and a certain temperature for a certain period of time, spraying the supercritical microemulsion to a collection kettle through a nozzle at a certain flow speed so as to form a nano-particle suspension, wherein the nozzle is of a detachable structure and comprises a spray head,a pressure sensor, a temperature sensor, a control system and a heating sleeve. According to the invention, in a low-temperature oxygen-free state, grease is wrapped in the wall material, so effective components in the grease are not easy to oxidize, the quality stability of the grease is obviously improved, the application range of the original easily-oxidized grease is greatly expanded, the consumption of the wall material in a supercritical emulsification process is small, embedding efficiency is good, and a surface oil rate is lower; and meanwhile, the nozzle monitors a medicine blockagecondition through the pressure sensor, and the problem of medicine blockage is solved through heating via the heating sleeve.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a preparation process of supercritical particles of oil. Background technique [0002] As the main component of body fat, unsaturated fatty acid oil is an indispensable fatty acid. Common unsaturated fatty acids in nature are mainly divided into three categories: omega-3 series unsaturated fatty acids represented by 20-carbon 5-enoic acid (EPA) and 2-carbon 6-enoic acid (DHA) contained in fish oil; The omega-6 series of unsaturated fatty acids represented by linoleic acid and the omega-9 series of unsaturated fatty acids represented by oleic acid contained in camellia oil. [0003] Studies have shown that because unsaturated fatty acid oils have a variety of biologically active substances (omega-3, omega-6 and omega-9 series of unsaturated fatty acids), most oils have the ability to prevent cardiovascular disease, hypertension, rheumatoid arthritis, depressio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J2/06
CPCB01J2/06
Inventor 胡勇刚
Owner 胡勇刚
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