Composition for treating and/or preventing cognitive disorder or dementia

A technology for cognitive impairment and dementia, applied in drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as clinical trials of people who do not use hydrogen inhalation, and achieve the prevention of cognitive impairment or dementia Effect

Pending Publication Date: 2020-11-27
MIZ CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are no reports of human clinical trials utilizing hydrogen inhalation

Method used

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  • Composition for treating and/or preventing cognitive disorder or dementia

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Embodiment 1

[0065] 1. first

[0066] Declining cognitive function is a major factor in aging, the most pronounced of the aging process and one of its most refractory features. Aging is clinically confounded with various symptoms, but until now various pharmacological / non-pharmacological means have been used to improve cognitive impairment associated with aging, but satisfactory results have not yet been obtained. Molecular hydrogen (H 2 ) is a new biological and medical gas with multifunctional therapeutic properties. Recently reported H 2 Improves cognitive impairment and neurodegenerative diseases in some animal models, but has not been evaluated for effectiveness in clinical trials in previous studies. We resolved 4 weeks of inhaled H in this open-label pilot experiment 2 The resulting effectiveness on cognitive function in women over 65 years of age.

[0067] 2. Materials and Methods

[0068] Participants (n=13) who voluntarily participated in this open-label pilot trial (Clinic...

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Abstract

Provided is a composition for treating and/or preventing cognitive disorder or dementia. This composition for treating and/or preventing cognitive disorder or dementia comprises hydrogen gas and is characterized in that the composition is used such that a subject inhales the hydrogen gas. For example, the concentration of the hydrogen gas to be inhaled is 0.5 to 18.3 volume%. For example, the concentration of the hydrogen gas to be inhaled is 1 to 10 volume%. For example, each inhalation duration of the hydrogen gas is at least 10 minutes and the number of inhalations of the hydrogen gas is atleast once a day.

Description

technical field [0001] The present invention relates to compositions for the treatment and / or prevention of cognitive impairment or dementia. Background technique [0002] With the advent of a super-aging society, the number of dementia patients in Japan is increasing rapidly. In particular, the number of patients estimated to be about 5 million in 2017 will increase to about 7 million in 2030. [0003] As the core of the treatment of Alzheimer's disease, which accounts for more than 60% of dementia, the use of acetylcholinesterase inhibitors has not shown improvement effect, but it is effective in delaying the progression. However, the status quo is that drug resistance develops as the disease progresses, and the deterioration cannot be dealt with. [0004] Therefore, although the development of a drug showing an improvement effect on Alzheimer's disease is expected, there has been no therapeutic drug showing an improvement effect on Alzheimer's disease and excellent safe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/00A61P25/28
CPCA61K33/00A61P25/28A61K9/007
Inventor S·M·奥斯托奇佐藤文平黑川亮介
Owner MIZ CO LTD
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