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Microneedle-assisted drug delivery system for keloid treatment

A drug delivery system and keloid technology, applied in the field of micro-needle-assisted drug delivery systems, can solve the problems of unbearable pain of drug injection and poor effect of external scar stickers, and achieve good medical effects.

Pending Publication Date: 2020-11-27
肖海涛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the deficiencies of the prior art, the present invention provides a microneedle-assisted drug delivery system for the treatment of keloids, which solves the problems of unbearable drug injection pain and poor effect of external scar patches during treatment

Method used

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  • Microneedle-assisted drug delivery system for keloid treatment
  • Microneedle-assisted drug delivery system for keloid treatment
  • Microneedle-assisted drug delivery system for keloid treatment

Examples

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Embodiment 1

[0034] like Figure 1-7 As shown, the embodiment of the present invention provides a microneedle-assisted drug delivery system for keloid treatment, including a skin-fitting fixation system, the skin-fitting system is connected with a dosing system, and the dosing system is connected with a nano-microneedle for administration System, the skin-fitting fixed system is connected with the pre-administration disinfection system, the skin-fitting fixed system fixes the pre-administration disinfection system and the nano-microneedle drug delivery system at the patient's position, and the skin-fitted fixed system is attached to the skin through the drug dosing system Drugs are added to the nano-microneedle drug delivery system to facilitate drug supply for the nano-microneedle drug delivery system, and the skin is disinfected through the disinfection system before administration, and the nano-micro-needle drug delivery system can be inserted into the skin and removed from the skin All...

Embodiment 2

[0047] Design and preparation of microneedle system

[0048] Using PMDS template casting method, select biocompatible materials such as hyaluronic acid, chitosan, gelatin and other degradable polymer matrix to prepare dissolvable microneedle system, including one-step casting method and segmented casting method to prepare tip drug loading Microneedles. The loaded fat-soluble drug is in the form of suspension or its soluble salt, and the water-soluble drug is directly injected into the microneedle template in a solution state, and after being cross-linked and solidified, it is irradiated and sterilized for use.

[0049] Based on our previous optimized clinical treatment plan for scars, the biocompatible hydrogel microneedle system loaded with triamcinolone acetonide and 5-fluorouracil is expected to improve the patient's compliance by replacing the existing injection administration method; and through The microneedle system continuously releases drugs in a small amount, degrad...

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Abstract

The invention provides a microneedle-assisted drug delivery system for keloid treatment, and relates to the technical field of keloid treatment. The microneedle-assisted drug delivery system for keloid treatment comprises a skin fitting and fixing system, wherein the skin fitting system is connected with a drug adding system; the drug adding system is connected with a nano microneedle drug delivery system; and the skin fitting and fixing system is connected with a pre-drug delivery disinfection system. The skin fitting and fixing system fixes the pre-drug delivery disinfection system and the nano-microneedle drug delivery system to a disease position, drugs are added into the skin fitting and fixing system through the drug adding system, drug supply to the nano-microneedle drug delivery system is facilitated, and the skin is subjected to disinfection through the pre-drug delivery disinfection system; and a nano drug delivery needle of the nano microneedle drug delivery system can automatically be disinfected before being punctured into the skin and when being taken out of the skin. According to the system, no obvious pain is caused during drug injection, drug absorption is promoted, and the treatment effect is good.

Description

technical field [0001] The invention relates to the technical field of keloid treatment, in particular to a microneedle assisted drug delivery system for keloid treatment. Background technique [0002] Keloid, commonly known as keloid, is an overgrown abnormal scar tissue formed after skin wound healing or skin injury caused by unknown reasons. Keloid can be roughly divided into two categories: primary type and secondary type. Primary keloids, mostly on the chest or back of the shoulders, start as small red spots with itching, gradually grow from small to large, from soft to hard, red or dark red, cord-shaped, butterfly-shaped, round, irregular shape etc. Secondary keloids are also called hypertrophic keloids, which are divided into: acne keloids and scar cancer. Mostly due to burns, trauma, acne, infection and suppuration, or closed by surgery, laser, freezing, skin grafting, and hormone drugs, it will cause excessive proliferation of damaged tissue and destruction and de...

Claims

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Application Information

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IPC IPC(8): A61M37/00A61M35/00
CPCA61M37/0015A61M35/10A61M2037/0023A61M2210/04A61M2037/0007A61M2037/0053A61M2037/0061A61M2210/005
Inventor 肖海涛邓珂杨倩
Owner 肖海涛
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