Cell filter

Abstract

The invention relates to a cell filter. The cell filter comprises a blood aspiration device, a blood filtration device and a blood recycling device; the blood recycling device comprises a waste liquidbottle and a vacuum pump; the vacuum pump is communicated with the waste liquid bottle; a blood aspiration needle is arranged in the blood aspiration device; the blood filtration device is correspondingly provided with an upper sealing cavity, a movable support plate and a lower sealing cavity in sequence from top to bottom; the lower sealing cavity is fixed on a lifting system; blood reaches a blood flow-in needle of the blood filtration device through the blood aspiration needle of the blood aspiration device, and then, reaches the waste liquid bottle through a filter film and a blood recycling pipeline; and the calibre of the blood aspiration needle is less than that of the blood flow-in needle. According to the cell filter in the invention, the blood aspiration needle is arranged at the input end; the blood flow-in needle is arranged at the output end; furthermore, the calibre of the aspiration needle is less than that of the flow-in needle; therefore, blood can be filtered by adoption of ultra-low negative pressure; the low pressure has little effect on cell damage; a new membrane pore structure is adopted; holes are same in size and arrangement form; and pollution of white blood cells on membrane pores is avoided.

Description

technical field [0001] The invention relates to the technical field of medical machinery, in particular to a cell filter. Background technique [0002] In the tumor cell capture technology based on cell shape and size (ISET), the excessive negative pressure generated by the vacuum system can easily lead to the destruction and death of tumor cells. At present, the IEST test requires pretreatment of blood, and the use of formaldehyde to fix the cells, so that the cells lose their vitality and cannot be used for the next stage of genetic research. The present invention does not need to treat blood preferentially, and protects cells as much as possible, and meanwhile, the captured cells are living tumor cells. [0003] CTC refers to tumor cells that originate from tumor tissue and circulate in the blood. CTC is the target of chemotherapy and the culprit of tumor metastasis and recurrence. Current research has confirmed that tumors release CTCs into the blood of patients at th...

AI Technical Summary

Problems solved by technology

In this way, there are no viable tumor cells for the next step of genetic testing

[0010] 3) The size and arrangement of the membrane pores of the ISET technology that uses polycarbonate to etch the membrane are inconsistent, which easily leads to the accumulation of white blood cells on the membrane, contaminates the membrane, and leads to low CTC capture rate and capture purity

[0011] 4) The degree of automation is low: manual cleaning of blood filters cannot effectively deal with large-scale sample testing

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