Application of ebiprazole in the preparation of antineoplastic drugs

A technology of anti-tumor drug, ebiprazole, applied in the field of medicine

Active Publication Date: 2022-02-11
ZHENGZHOU UNIV
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are no studies on the effect of ebiprazole on cancer, es

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of ebiprazole in the preparation of antineoplastic drugs
  • Application of ebiprazole in the preparation of antineoplastic drugs
  • Application of ebiprazole in the preparation of antineoplastic drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0025] Materials and Methods

[0026] 1. Materials

[0027] Esophageal squamous cell carcinoma cells KYSE150, KYSE450 and gastric cancer cells HGC27, AGS were from the Department of Pathophysiology, School of Basic Medicine, Zhengzhou University

[0028] 1.1 Cell line: KYSE150 cell line, the cell line uses 1640 medium containing 10% FBS, 37 ℃ constant temperature, 5% CO 2 Cultivate and reserve under conditions.

[0029] KYSE450 cell line, the cell line uses DMEM medium containing 10% FBS, 37 ℃ constant temperature, 5% CO 2 Cultivate and reserve under conditions.

[0030] HGC27 cell line, the cell line uses 1640 medium containing 10% FBS, 37 ℃ constant temperature, 5% CO 2 Cultivate and reserve under conditions.

[0031] AGS cell line, the cell line uses F12K medium containing 10% FBS, 37 ℃ constant temperature, 5% CO 2 Cultivate and reserve under conditions.

[0032] Culture method: Culture in 8ml-10ml culture medium in a petri dish with a diameter of 10cm, and change t...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses the application of ebiprazole in the preparation of antineoplastic drugs, ebiprazole, chemical name: 7-[4-(benzo[B]thiophene-4-1-piperazine)butoxy]-2 (1H)-Quinolinone, CAS No. 913611-97-9, molecular formula C 25 h 27 N 3 o 2 S, the molecular weight is 433.57. The antitumor drug is a drug for treating esophageal cancer or gastric cancer. This application has proved through experiments that ebiprazole can inhibit the growth of esophageal squamous cell carcinoma cells or gastric carcinoma cells and transformation, and the appropriate concentration of ebiprazole to inhibit the proliferation and transformation of esophageal squamous cell carcinoma cells or gastric cancer cells is 2.5 μM to 10 μM.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of ebiprazole in the preparation of antitumor drugs. Background technique [0002] One of the defining features of cancer is the rapid production of abnormal cells that grow beyond normal limits and are thus able to invade adjacent parts of the body and spread to other organs. Symptoms of early gastric cancer are non-specific, while advanced gastric cancer often has typical clinical manifestations, endoscopic diagnosis is not difficult, but the 5-year survival rate is significantly lower than that of early gastric cancer. Given that the occurrence and development of esophageal cancer and gastric cancer is a multi-step process from chronic inflammation-dysplasia-tumor, which takes a long time, chemoprevention has a direct impact on the occurrence of tumors. [0003] Cancer is the result of the synergistic effect of environment, diet, lifestyle and genetic facto...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/496A61P35/00
CPCA61K31/496A61P35/00
Inventor 刘康栋董子钢韦亚星赵继敏赵四敏江亚南董子明
Owner ZHENGZHOU UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap