Compound having novel structure, Anti-inflammatory agent comprising same, and cyclooxygenase-2 inhibitor comprising same

Abstract

In the compound of the present invention and in an anti-inflammatory agent, a cyclooxygenase-2 inhibitor, a therapeutic agent for brain diseases, and an MRI contrast medium, which each comprise the same compound, the compound of the present invention has the structure represented by chemical formula 1 according to the present invention.

Description

technical field [0001] The present invention relates to a compound with a new structure, more specifically, to a compound with a new structure that has a higher self-relaxation rate and can target and treat inflammation sites, and at the same time, can diagnose and treat inflammation , Anti-inflammatory agents and cyclooxygenase-2 inhibitors including the same. Background technique [0002] Inflammatory mediators are factors that play an important pathogenic role in the occurrence, spread, and persistence of pain and inflammation, and the main inflammatory mediators include prostaglandin. [0003] Nonsteroidal anti-inflammatory drugs (NSAIDs) are substances used for acute and chronic diseases with pain and inflammation by blocking cyclooxygenase (COX) involved in the biosynthesis of prostaglandins. Usually, NSAID blocks the synthesis of prostaglandins of arachidonic acid by blocking cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) Relieves pain and relieves inflammati...

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Problems solved by technology

[0004] However, COX-2 is rarely expressed at ordinary times, and part of the inflammatory response caused by harmful stimuli is rapidly induced to express and participate in the inflammatory response, but most of the tissues of COX-1 are expressed and participate in maintaining normal cell functions, thus, responsible for Maintain the protection of the gastrointestinal mucosa, the homeostasis of blood vessels, the aggregation of platelets, and the homeostasis of renal function. Therefore, the inhibition of COX-1 will cause gastrointestinal hemorrhage and cardiovascular diseases that occur in the gastrointestinal tract and cardiovascular system. Serum reaction, myocardial infarction, stroke and other side effects

[0005] Therefore, in order to avoid this abnormal reaction, anti-inflammatory substances that can selectively inhibit only COX-2, which is expressed by the inflammatory response to sustain and aggravate the inflammatory response, are required. However, most of the existing NSAIDs inhibit COX-1 and COX -2, therefore, there is also a need to develop novel anti-inflammatory substances that exhibit selective inhibitory properties against COX-2

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