A kind of preparation method of testosterone propionate
A technology of testosterone propionate and hydroxyandrosterol, applied in the field of drug preparation, can solve the problems of excessive waste water, low yield, large impurities, etc., and achieve the effects of less environmental pollution, high purity, and high product quality and yield
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example 1
[0021] Example 1 Preparation of testosterone propionate
[0022] Under a nitrogen atmosphere, 10g of testosterone (17p-hydroxy-androst-4-en-3-one) were charged to a 10ml of dichloromethane, 1ml of pyridine was added, 5g 4- dimethylaminopyridine (of DMAP), propionic anhydride was added 10ml , incubated 20 ℃ the reaction to completion, water was added, layered, washing, concentration, filtration, and dried to obtain 11.1 g of testosterone propionate, yield 111%, purity: 98.9%.
example 2
[0023] Example 2 Preparation of testosterone propionate
[0024] Under an argon atmosphere, 10g of testosterone (17p-hydroxy-androst-4-en-3-one) were charged to 100ml of dichloroethane, was added 100ml of triethylamine, 10g 4- dimethylaminopyridine (DMAP) was , 50ml propionic anhydride was added, incubated 50 deg.] C until complete reaction, water was added, layered, washing, concentration, filtration, and dried to obtain 11.2 g of testosterone propionate, yield 112%, purity: 98.8%.
example 3
[0025] Example 3 Preparation of testosterone propionate
[0026] Under helium atmosphere, 10g of testosterone (17p-hydroxy-androst-4-en-3-one) were charged to a 200ml of dichloromethane was added diisopropylethyl amine 50ml, 0.01g 4- dimethylaminopyridine (of DMAP), propionic anhydride was added 4.5ml, incubated 80 deg.] C until complete reaction, water was added, layered, washing, concentration, filtration, and dried to obtain 11.1 g of testosterone propionate, yield 111%, purity: 98.7%.
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