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Intestinal flora regulator and application thereof

A technology of intestinal flora and regulator, applied in the field of medicine, can solve the problems of the anti-tumor effect and mechanism of icariin I, but few researches, etc., so as to enhance the immunity of the host and improve the metabolism. , the effect of increasing the level

Inactive Publication Date: 2020-11-03
FOSHAN GOLDEN HEALTH TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, epimedium extracts have been reported to have a variety of antitumor activities, but there are few studies on the antitumor effects and mechanisms of icariside I, especially on its impact on intestinal flora

Method used

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  • Intestinal flora regulator and application thereof
  • Intestinal flora regulator and application thereof
  • Intestinal flora regulator and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Intestinal flora modulator inhibits the growth of melanoma in mice and regulates intestinal flora

[0047] (1) Modeling: A melanoma tumor-bearing mouse model was constructed using mouse melanoma B16 cells.

[0048] (2) Grouping: Taking the unmodeled normal mice as the normal group of group A, the melanoma B16 mouse model made in step (1) was randomly divided into groups B, C, D, and E; a total of 5 groups, each Group of 8 mice.

[0049] (3) Administration: administration by intragastric administration, administration with corn oil as the drug carrier, continuous administration for 7 days, wherein:

[0050] Group A and B were given corn oil, 0.2ml each time;

[0051] Group C was a low-dose group, given icariside I at 5 mg / kg·BW;

[0052] Group D is the middle-dose group, given icariside I at 20 mg / kg·BW;

[0053] Group E was a high-dose group, given icariside I at 80 mg / kg·BW.

[0054](4) Observation and recording: During the period of administration, observe the mo...

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Abstract

The invention discloses an intestinal flora regulator. The intestinal flora regulator comprises icarisid I. The intestinal flora regulator can regulate the structure of intestinal flora, improve the metabolism of the flora, convert the intestinal flora of a patient into a healthy intestinal flora outline, enhance the immunity of a host and resist and inhibit cancers, and can be applied to the fields of medicines, foods and the like. The invention further discloses an application of the intestinal flora regulator to increment of the content of intestinal probiotics and the content of intestinalflora secondary metabolites, and an application of the intestinal flora regulator to preparation of functional foods, anti-cancer drugs or cancer immunotherapy. The content of lactobacillus and bifidobacterium in intestinal tracts can be increased, and generation of metabolite short-chain fatty acid is promoted; the intestinal flora regulator is free from toxic or side effects, can be used for daily eating, regulates intestinal flora and improves immunity; the icariside I has a good inhibition effect on tumor cells, and can also improve the low reaction rate of a patient to tumor immunotherapy and possible side effects; and a new direction is provided for the application of the icariside I.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an intestinal flora regulator comprising icariside I and an application thereof. Background technique [0002] In recent years, the relationship between intestinal flora and cancer has been paid more and more attention, and intestinal flora has been found to be closely related to the efficacy of cancer treatment, including chemotherapy, radiotherapy and immunotherapy. Recent studies have found that the intestinal flora of cancer patients is significantly different from that of healthy people; the structure and composition of intestinal flora are also quite different between patients who respond well to tumor immunotherapy and those who respond poorly, which may It is suggested that the intestinal flora plays an important role in the process of patient tumor immunotherapy. At present, it has been reported that a variety of intestinal bacterial strains can promote anti-tumor effe...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K9/00A23L33/105A61K36/296A61P35/00A61P37/04
CPCA23V2002/00A61K9/0053A61K31/7048A61K36/296A23L33/105A61P35/00A61P37/04A23V2250/21A23V2200/308A23V2200/32
Inventor 陈桂李慧灵林丽薇卢宇靖周金林叶德晓林育成邓诚
Owner FOSHAN GOLDEN HEALTH TECH CO LTD
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