CircRNA related to malignant melanoma and application of circRNA

A melanoma-specific technology, applied in the field of biomedicine, can solve the problem of undetermined clinical diagnostic efficacy

Pending Publication Date: 2020-10-30
云南省肿瘤医院
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, circRNA (circRNA0012891) has not been applied to distinguish MM meta

Method used

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  • CircRNA related to malignant melanoma and application of circRNA
  • CircRNA related to malignant melanoma and application of circRNA
  • CircRNA related to malignant melanoma and application of circRNA

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Embodiment Construction

[0036] The implementation mode of the present invention is illustrated by specific specific examples below, and those who are familiar with this technology can easily understand other advantages and effects of the present invention from the contents disclosed in this description. Obviously, the described embodiments are a part of the present invention. , but not all examples. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0037] The chip adopts CapitalBio Technology Human CircRNA Array v2, and the format is designed as 4X180K. The chip fully covers CircBase, DeepBase and Rybak-Wolf20151 database, and can detect 170340 kinds of circRNA at the same time. This chip is designed for each circRNA with 60mer and 50mer detection probes Dual-probe design, the detection data are mutually confirmed, and the probe covers the ...

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Abstract

The invention discloses circRNA related to malignant melanoma and application of the circRNA, and belongs to the technical field of biological medicine. The circRNA in the application is circRNA _ 0012891, and it is found for the first time that the expression level of circRNA _ 0012891 is related to melanoma metastasis. The invention provides a circRNA diagnostic marker which is circRNA _ 0012891, and also provides a product which can be used for diagnosing whether melanoma metastasis exists or not, and improving the survival rate and the life quality of melanoma patients through advanced detection.

Description

technical field [0001] The embodiment of the present invention relates to the field of biomedical technology, in particular to a circRNA related to malignant melanoma and its application. Background technique [0002] Melanoma, also called malignant melanoma (MM), accounts for about 1% to 3% of all malignant tumors. Cutaneous melanoma (CMM) is an aggressive tumor derived from the malignant transformation of epidermal melanocytes. It is the malignant tumor with the fastest progression and the poorest prognosis among all skin tumors, with blood supply or lymph node metastasis in the later stage. Its onset is insidious, and it is prone to early metastasis. Most of the patients who seek medical treatment are in the middle and late stages, and the mortality rate within 5 years of metastasis is high. In recent years, the morbidity and mortality of MM have shown an obvious upward trend. The American Cancer Society (ACS) reported in 2017 that, except for the morbidity and mortality...

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Application Information

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IPC IPC(8): C12Q1/6886G01N33/53G01N33/574G01N33/68A61K45/00A61P35/00
CPCC12Q1/6886G01N33/5308G01N33/5743G01N33/57484G01N33/6854A61K45/00A61P35/00C12Q2600/178C12Q2600/158C12Q2600/136
Inventor 陈龙孙华杨聪慧谢燃赵升汪春李淑娟蒋婕李韵蕾
Owner 云南省肿瘤医院
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