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Application of fingolimod in inhibiting activity of gram-positive bacteria

A gram-positive bacteria, active technology, applied in the field of medicine, can solve problems such as antibacterial activity that has not yet been found

Pending Publication Date: 2020-10-23
华中科技大学协和深圳医院
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

After consulting the literature, it was found that no research on the antibacterial activity of the drug has been found so far

Method used

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  • Application of fingolimod in inhibiting activity of gram-positive bacteria
  • Application of fingolimod in inhibiting activity of gram-positive bacteria
  • Application of fingolimod in inhibiting activity of gram-positive bacteria

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Embodiment Construction

[0043] The preferred embodiments of the present invention will be further described in detail below.

[0044] A variety of Gram-positive bacteria (including Staphylococcus aureus, Enterococcus faecalis, and Streptococcus agalactiae, etc.) are common opportunistic pathogens in nosocomial infections and community-acquired infections. With the widespread and frequent use of antimicrobials, the world The infection rate of MRSA is rising all over the world, which is a serious threat to human life and health, and the emergence of vancomycin-resistant Staphylococcus aureus has exacerbated this form, and it is urgent to develop new anti-Staphylococcus aureus drugs.

[0045] Fingolimod is clinically used for multiple sclerosis, but also for neurological diseases such as stroke. Although it has been used clinically for many years, there is no research report on its anti-infection. The present invention finds the new application of fingolimod for anti-multiple Gram-positive bacterial ac...

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Abstract

The invention provides an application of fingolimod in inhibiting the activity of gram-positive bacteria. The fingolimod is used for inhibiting the activity of gram-positive bacteria growth. The technical scheme of the invention discloses a new application of fingolimod, and the fingolimod has antibacterial activity and a low MIC value in various gram-positive bacteria such as staphylococcus aureus, enterococcus and streptococcus agalactiae, especially in the environment of staphylococcus aureus, fingolimod has a relatively strong bactericidal effect on staphylococcus aureus, and the MIC valueis generally 3.125 [mu] g / mL; the formation of a staphylococcus aureus biological membrane can be obviously inhibited at 1 / 2MIC; besides, when the concentration of fingolimod is 2 * MIC, the fingolimod has shown the ability to remove the staphylococcus aureus biofilm, and when the concentration is greater than or equal to 4 * MIC, the fingolimod can significantly remove the staphylococcus aureusbiofilm. Fingolimod can also induce a significant decline in the ability of formation of the staphylococcus aureus biological membrane

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the use of fingolimod for inhibiting the activity of Gram-positive bacteria. Background technique [0002] Staphylococcus aureus, referred to as Staphylococcus aureus, is one of the common pathogens of hospital and community-acquired infections, and it is also one of the most common life-threatening bacterial infections. It can cause a series of suppurative infections and food poisoning, and even cause Severe life-threatening diseases such as sepsis and toxic shock syndrome. With the widespread use of antibacterial drugs, the detection rate of drug resistance of Staphylococcus aureus continues to increase, especially methicillin-resistant Staphylococcus aureus (MRSA), and even vancomycin-resistant Staphylococcus aureus (VRSA). With increasing numbers, Staphylococcus aureus may break through the last line of defense of human antibiotics and directly threaten human li...

Claims

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Application Information

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IPC IPC(8): A61K31/137A61K31/431A61P31/04A61L31/08A61L31/16
CPCA61K31/137A61K31/431A61P31/04A61L31/08A61L31/16A61L2300/216A61L2300/404
Inventor 余治健王占文熊焱鹏邓启文
Owner 华中科技大学协和深圳医院
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