Tail clamping device for depression animal model construction, expression image acquisition system, model construction method and application

Abstract

T The invention relates to the technical field of biology, and particularly discloses a tail clamping device for depression animal model construction, an expression image acquisition system, a model construction method and application. The tail clamping device for depression animal model construction is simple in structure, a groove is formed in a clamping part of the tail clamping device, a clamping hole is formed when the clamping part of the tail clamping device is engaged, the clamping hole can be engaged with the tail of an experimental animal, the stress surface of the tail of the experimental animal is dispersed through the hole shape of the clamping part of the tail clamping device, the stress of the tail of the experimental animal is more uniform, and therefore the situations of damage and bleeding of the tail of the experimental animal are reduced.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a tail pinching device used in the construction of an animal model of depression, an expression image collection system, a construction method and the application of the model. Background technique [0002] Depression is the most common mood disorder, with more than 300 million depressed patients worldwide. At least 800,000 people with depression commit suicide every year. The lifetime prevalence of depression is 12%-17%. The etiology of depression is currently unknown and clinical antidepressants have low efficacy, slow onset, large side effects, and high recurrence rate after drug withdrawal. urgent scientific problems to be solved. [0003] To solve this problem, animal models of human diseases have contributed. Animal models of human diseases are animal experimental objects and materials with human disease simulation performance established in medical science research, and ar...

AI Technical Summary

Problems solved by technology

In the laboratory, experimenters often grab mice with bare hands, which has the following problems: firstly, in the process of grabbing, rats are prone to scratch or bite experimenters; secondly, for some female experimenters, it may be Strong psychological barriers to catching rats with bare hands

The commonly used method is to use a camera for single-frame shooting or video recording. However, the photos after shooting are prone to human judgment errors for inexperienced experimenters, which will cause errors in the experimental results.

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