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Personal care product acute and chronic dose-effect relationship characterization method

A personal care, acute and chronic technology, applied in the field of environmental science and engineering, which can solve the problems that there are no personal care products such as acute and chronic toxicity test and dose-response relationship characterization method.

Inactive Publication Date: 2020-10-20
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, so far, there are no acute and chronic toxicity tests and dose-effect relationship characterization methods for various personal care products on the market

Method used

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  • Personal care product acute and chronic dose-effect relationship characterization method
  • Personal care product acute and chronic dose-effect relationship characterization method
  • Personal care product acute and chronic dose-effect relationship characterization method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] [Example 1] Acute and Chronic Dose-Effect Relationship Characterization of Adidas Men's Shurun ​​Muscle Energy Water

[0061] (1) Purchase Adidas Men's Soothing Skin Energy Water from the brand's official website and store it in a room at 22°C. The original solution is directly used as stock solution 1, and diluted 10 times, 100 times and 1000 times respectively to obtain stock solution 2,3, 4. Place them in a room with the same temperature. The diluted samples should be stored for 3 days. Use a 96-well microplate as the carrier, press figure 1 Add the plate as indicated, and use a 10μL-100μL 12-channel pipette in the experimental group to sequentially take 100μL, 50μL, and 20μL of each stock solution and add them to B1-D1, B2-D2, and B3-D3 respectively. A single-channel pipette can also be used. Sampling, each volume was repeated at least 3 times and arranged in the same row of 3 wells, or horizontally, and then repeated the above steps to take out 10-fold and 100-fold...

Embodiment 2

[0065] [Example 2] Characterization of acute and chronic dose-effect relationship of Shiseido Water Print Elastic Collagen Moisturizing Water

[0066] (1) Purchase Shiseido Mizuyin Elastic Collagen Moisturizing Water from the brand's official website and store it in a room at 22°C. The original solution is directly used as stock solution 1, and diluted 10 times, 100 times and 1000 times respectively to obtain stock solutions 2, 3, and 4. and placed in the room at the same temperature, the diluted samples were stored for 3 days, with 96-well microplate as the carrier, according to figure 1Add the plate as indicated, and use a 10μL-100μL 12-channel pipette in the experimental group to sequentially take 100μL, 50μL, and 20μL of each stock solution 1 and add them to B1-D1, B2-D2, and B3-D3 respectively. Single-channel pipetting can also be used. Gun sampling, repeat each volume at least 3 times and arrange in the same row of 3 wells, or vertically, then repeat the above steps to t...

Embodiment 3

[0070] [Example 3] Characterization of acute and chronic dose-effect relationship of Ji Rui (Za) multi-component water active and moisturizing lotion

[0071] (1) Purchase Jirui (Za) multi-component water moisturizing lotion from the brand's official website, and store it in a room at 22°C. Use the original solution directly as stock solution 1, dilute it 10 times, 100 times and 1000 times respectively to obtain stock solution 2, 3,4, and placed in the room at the same temperature, the storage time of the diluted sample is 3 days, with a 96-well microplate as the carrier, according to figure 1 Add the plate as indicated, and use a 10μL-100μL 12-channel pipette in the experimental group to sequentially take 100μL, 50μL, and 20μL of each stock solution 1 and add them to B1-D1, B2-D2, and B3-D3 respectively. Single-channel pipetting can also be used. Gun sampling, repeat each volume at least 3 times and arrange in the same row of 3 wells, or vertically, then repeat the above step...

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Abstract

The invention belongs to the field of environmental science and engineering, and discloses a personal care product acute and chronic dose-effect relationship characterization method. The method mainlycomprises the steps of obtaining a dilution factor microplate test; determining S-shaped and J-shaped dose-effect relationship dilution factors; carrying out dose-effect curve fitting; and drawing athree-dimensional dose-effect curve graph. The method disclosed by the invention is beneficial to researching the dose-effect relationship of commodity type actual environmental pollutants with unknown components and unknown concentrations.

Description

technical field [0001] The invention belongs to the field of environmental science and engineering, and in particular relates to a characterization method for acute and chronic dose-effect relationships of personal care products. Background technique [0002] Personal care products include skin care products, perfumes, anti-ultraviolet agents, preservatives, insecticides, disinfectants, etc., which are common in daily life. Skin care products include a large number of chemically synthesized makeup and cleaning products with different functions. Water, lotion, moisturizer, facial cleanser, shampoo, body wash, sunscreen and other products. According to the national data of the National Bureau of Statistics, the turnover of cosmetics in 2018 was 29.929 billion yuan (http: / / data.stats.gov.cn / easyquery.htm?cn=C01). Personal care products have been detected in various environmental matrices in different countries and regions, and have become a new class of pollutants with potenti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/50
CPCG01N33/5014
Inventor 徐雅倩刘树深王泽君黄朋
Owner TONGJI UNIV
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