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Application of pathological specimen manufactured by dehydration set in digital evaluation system

An evaluation system and pathological technology, applied in the preparation of test samples, laboratory analysis data, measuring devices, etc., can solve problems such as reduction, error, and inability to complete pathological specimens

Pending Publication Date: 2020-10-20
THE AFFILIATED HOSPITAL OF QINGDAO UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Conventional paraffin section technique has large tissue shrinkage rate, poor flexibility, serious deformation during dehydration process, unable to complete computer-assisted restoration of pathological specimens, and can only be spliced ​​by PS technique, and this splicing method often has errors, which cannot achieve to a precise description of the margin
Greatly limit the application of computer-aided means in tumor diagnosis and treatment

Method used

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  • Application of pathological specimen manufactured by dehydration set in digital evaluation system
  • Application of pathological specimen manufactured by dehydration set in digital evaluation system
  • Application of pathological specimen manufactured by dehydration set in digital evaluation system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0101] In Example 1, the application of gastrointestinal specimens in a digital evaluation system in endoscopic submucosal resection (ESD for short) made by using a dehydration suit is disclosed.

[0102] S1: Enter basic patient information.

[0103] S2: Pathological tissue pretreatment.

[0104] The diseased tissue was fixed with 4% neutral formaldehyde fixative for 15 hours, rinsed with running water for 20-30 minutes, and then fixed with aldehyde-free fixative for 3 hours. After the surface of the tissue was hardened, the tissue was stained, marked, and photographed without washing.

[0105] S3: Collect materials.

[0106] The diseased tissues after taking pictures were collected comprehensively and as a whole, and the sorting of the collected tissues was numbered and photographed.

[0107] S4: Dehydration treatment.

[0108] The collected tissues were fixed with 4% neutral formaldehyde fixative, then treated with aldehyde-free fixative, dehydrating agent and clearing ag...

Embodiment 2

[0125] Embodiment 2 discloses the application of liver tumor specimens prepared by using a dehydration suit in a digital evaluation system. The application method is the same as that in Example 1, except that liver tumor samples are selected.

[0126] Such as Figure 4 As shown in (4a-4c), the liver tumor is completely dehydrated, the tissue is embedded flat, and the slice integrity and continuity are good, which is beneficial to the computer evaluation system; in the shrinkage experiment, the shrinkage rate of the liver tumor specimen made by the dehydration suit is only 6-10%. It is beneficial to the measurement and labeling under the computer evaluation system; the effect of tissue degreasing treatment is complete, and the large tissue slices are complete, which is conducive to the observation of tissue slices. further as Image 6 As shown, the dehydration suit can be used to process normal liver tissue because of its good toughness, the slices do not need to be repeatedl...

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Abstract

The invention discloses application of a pathological specimen manufactured by a dehydration set in a digital evaluation system, belongs to the field of computer-assisted medical treatment, and can solve the problem that a traditional slicing technology cannot be used for digital evaluation of tumor diagnosis and treatment. A tissue slice is manufactured by utilizing the dehydration set and an optimized dehydration process, the specimen is good in flexibility, tissue embedding is facilitated, and the tissue slice is particularly suitable for thin, long and thin strip tissues with the length of3 cm or above and large tissues with the length of 5 cm or above; the tissue shrinkage rate is low, cell-level point-to-point measurement under a computer is facilitated, and the true appearance of an original specimen is restored; hundreds of slices can be continuously sliced in three-dimensional reconstruction, wax blocks do not need to be repeatedly frozen, and the real face of the specimen can be accurately restored. The pathological specimen can be widely applied to postoperative pathological evaluation of tumor specimens of single-incision tumor specimens, all organ tumors, omentum tissues with lymph nodes on the periphery and associated organ tissues.

Description

technical field [0001] The invention belongs to the field of computer-aided medical treatment, and in particular relates to the application of a pathological specimen made by using a dehydration suit in a digital evaluation system. Background technique [0002] At present, computer-aided means are widely used in the medical field for diagnosis and treatment of diseases. Among them, the digital evaluation of pathological specimens needs to restore the true face of pathological specimens to the greatest extent, and has high requirements for the shrinkage rate, damage and connection rate of pathological specimens after dehydration. [0003] In the diagnosis of tumors, the most direct and effective method is to perform subjective visual judgment on the microscopic histology of the fixed tissue sections of the involved organs. Now the tissue paraffin section technique is commonly used to slice the diseased tissues. Conventional paraffin section technique has large tissue shrinka...

Claims

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Application Information

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IPC IPC(8): G01N1/28G01N1/30G01N21/84G16H10/40G16H30/20G16H50/20
CPCG01N1/28G01N1/30G01N21/84G16H10/40G16H30/20G16H50/20
Inventor 赵洁李明夏楠王凤娇王菲菲
Owner THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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