An immunohistochemical digital slide reading system and method
A technology for immunohistochemistry and slide reading, which is applied in image data processing, character and pattern recognition, image enhancement, etc. It can solve the problems of low reading efficiency, long time-consuming manual reading of immunohistochemical digital slides, etc., and achieve simplification Effects of the diagnostic process
Active Publication Date: 2021-01-08
武汉中纪生物科技有限公司
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[0017] Aiming at the above deficiencies or improvement needs of the prior art, the present invention provides a system and method for reading immunohistochemical digital slides. By performing feature matching on the images of immunohistochemical digital slides and superimposing them for display, it is convenient for doctors to Quickly find typical features in multiple images and quickly switch between different immune index images, improving the efficiency and accuracy of reading, and correspondingly can effectively solve the problem of manual reading of immunohistochemical digital slides by existing doctors. It takes a long time and the technical problems of low reading efficiency, so it is especially suitable for the application of digital slide image reading of pathological tissue immunohistochemistry
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[0077] Such as figure 2 As shown, the same pathological tissue sample was made into a conventionally stained section (ie, HE section) and multiple immunohistochemical sections (respectively three indicators of CD10, CD5, and MUM-1). Due to the reasons of slide preparation and staining, the positions, angles, and staining depths of each tissue on the slide are different.
[0078] First, use the image acquisition module of the slide scanner to scan the HE slice and the above three immunohistochemical slides to obtain the digital image of the immunohistochemical slide after digital scanning. The scanning process uses a 40x objective lens to scan, and the scanning resolution is higher than 0.24 Micrometers per pixel, and the digital images are all zoomable full size images.
[0079] The image acquisition module sends the four scanned immunohistochemical image information to the image pyramid creation module, and the pyramid creation module creates image pyramids with 6 zoom leve...
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The invention belongs to the technical field of pathological immunohistochemical slide reading, and more specifically relates to an immunohistochemical digital slide reading system and method. It includes an image acquisition module, an image pyramid creation module, an image matching module and an image overlay display module, the image acquisition module is used to acquire digital images of immunohistochemical digital slides; the image pyramid creation module is used for each digital image The image creates an image pyramid with the same number of zoom levels; the image matching module is used to match the image features of each image on the same zoom level in the image pyramid, and outputs the image matching result; the image overlay display module is used for according to the image The displacement offset and rotation angle deviation output by the matching module are adjusted to adjust the displacement and rotation angle of each image, and an overlay display result is output. Physicians can quickly find typical features in multiple images and quickly switch between different immune index images to improve the efficiency of image reading.
Description
technical field [0001] The invention belongs to the technical field of pathological immunohistochemical slide reading, and more specifically relates to an immunohistochemical digital slide reading system and method. Background technique [0002] Immunohistochemistry is the abbreviation of immunohistochemical analysis. It is the basic principle of applied immunology - antigen-antibody reaction, that is, the principle of specific combination of antigen and antibody. Ion, isotope) color development to determine the antigens (polypeptides and proteins) in tissue cells, and carry out localization, qualitative and relative quantitative research on them. [0003] The clinical application of immunohistochemistry mainly includes the following aspects: [0004] (1) Diagnosis and differential diagnosis of malignant tumors; [0005] (2) Determine the primary site of the metastatic malignant tumor; [0006] (3) Carry out further pathological classification of certain types of tumors; ...
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IPC IPC(8): G01N21/84G01N1/30G06T7/00G06K9/62
CPCG01N21/84G01N1/30G06T7/0012G06T2207/20016G06V10/752
Inventor 张珺梅春明狄媛媛
Owner 武汉中纪生物科技有限公司
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