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Method for producing L-malic acid and co-producing succinic acid

A technology of malic acid and succinic acid, applied in organic chemical methods, separation/purification of carboxylic acid compounds, organic chemistry, etc., can solve the problem of lack of high-efficiency production of L-malic acid and co-production of succinic acid, low product purity, solvent Residue and other problems, to achieve the effect of reducing the decolorization load, high purity, and increased yield

Active Publication Date: 2020-10-02
ANHUI BBCA FERMENTATION TECH ENG RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing acid dissociation and handover process has low product purity and low yield
Conventional organic solvent extraction has problems such as difficult stripping, low product purity, and solvent residues
And this area still lacks a kind of method that can efficiently produce L-malic acid co-production succinic acid

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] This example provides a method for producing L-malic acid and co-producing succinic acid. The method uses 33.27 kg of fermented liquid containing calcium malate and calcium succinate obtained by fermentation to produce L-malic acid as raw material, and proceeds as follows operate:

[0031] The raw materials of the fermentation broth were heated to 60°C and centrifuged to obtain 8.06 kg of solids containing L-calcium malate and calcium succinate and 25.15 kg of filtrate containing L-calcium malate and calcium succinate;

[0032] The solid containing L-calcium malate and calcium succinate is carried out comprising the following steps:

[0033] (1) Mix the solid with 8.06kg of water for slurrying, add sulfuric acid until the pH of the slurry is 3.0 for acidolysis, heat and filter to obtain 9.18kg of filter cake and 10.57kg of filtrate, adjust the temperature of the filtrate to 20°C, and filter to obtain L - Calcium hydrogen malate wet crystals 3.5kg;

[0034] (2) Mix the...

Embodiment 2

[0041] This embodiment provides a method for producing L-malic acid and co-producing succinic acid. The method uses 32.45 kg of fermented liquid containing calcium malate and calcium succinate obtained from producing L-malic acid by fermentation as raw material, and proceeds as follows operate:

[0042] The raw materials of the fermentation broth were heated to 70° C., and centrifuged to obtain 8.18 kg of solids containing L-calcium malate and calcium succinate and filtrates containing L-calcium malate and calcium succinate;

[0043] The solid containing L-calcium malate and calcium succinate is carried out comprising the following steps:

[0044] (1) Take 500g of wet L-calcium malate and calcium succinate and add 350g of water to make slurry, add the mother liquor of L-malic acid and succinic acid obtained in Example 1 to acidolysis to pH2.9, and filter at 85°C , to obtain 720g of filtrate, lower the temperature to 10°C, filter to obtain 460g of L-calcium hydrogen malate fil...

Embodiment 3

[0049] This embodiment provides a method for producing L-malic acid and co-producing succinic acid. The method uses 32.45 kg of fermented liquid containing calcium malate and calcium succinate obtained from producing L-malic acid by fermentation as raw material, and proceeds as follows operate:

[0050] heating the raw materials of the fermentation broth to 70°C, and centrifuging to obtain a solid containing L-calcium malate and calcium succinate and a filtrate containing L-calcium malate and calcium succinate;

[0051] The solid containing L-calcium malate and calcium succinate is carried out comprising the following steps:

[0052] (1) Take 500g of wet L-calcium malate and calcium succinate and add 350g of filtered L-calcium hydrogen malate to prepare slurry, add sulfuric acid to acidify to pH2.1, filter at 90°C to obtain 705g of filtrate, add Adjust the pH to 3.2 with calcium carbonate and cool down to 10°C, filter to obtain 410g of L-calcium hydrogen malate filter cake, ...

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Abstract

The invention provides a method for producing L-malic acid and co-producing succinic acid. The method comprises the following steps of: taking fermentation liquor or enzymatic conversion liquor containing L-calcium malate and calcium succinate obtained by producing L-malic acid by a fermentation method or an enzymatic conversion method as a raw material, carrying out solid-liquid separation to respectively obtain a solid containing L-calcium malate and calcium succinate and a liquid containing L-calcium malate and calcium succinate; carrying out multi-step treatment on the solid by adopting anacidolysis method to obtain an L-malic acid product; and carrying out multi-step treatment on the liquid by utilizing ion exchange resin to obtain a succinic acid product. According to the method provided by the invention, separation of L-malic acid and succinic acid in the fermentation liquor is realized, and meanwhile, the yield of L-malic acid and succinic acid is greatly increased. The L-malic acid and succinic acid obtained by the method are high in purity and good in quality.

Description

technical field [0001] The invention relates to the field of food chemical industry, in particular to a method for producing L-malic acid and co-producing succinic acid. Background technique [0002] Malic acid, also known as 2-hydroxysuccinic acid, has two stereoisomers due to an asymmetric carbon atom in the molecule. In nature, it exists in three forms, namely D-malic acid, L-malic acid and its mixture DL-malic acid. Malic acid is a white crystal or crystalline powder, which has strong hygroscopicity and is easily soluble in water and ethanol. Has a particularly pleasant sour taste. L-malic acid is mainly used in the food and pharmaceutical industries. [0003] Succinic acid, also known as succinic acid, is a colorless crystal, soluble in water, slightly soluble in ethanol, ether and acetone. In industry, it is often prepared by the catalytic reduction of butenedioic acid, and it can also be prepared by the hydrolysis of succinonitrile. Fermentative production of suc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/42C07C55/10C07C59/245
CPCC07C51/42C07B2200/07C07C55/10C07C59/245
Inventor 李荣杰潘声龙胡富贵张渊纪传侠
Owner ANHUI BBCA FERMENTATION TECH ENG RES
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