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Method and device for continuously producing sartan biphenyl

A technology of sartan biphenyl and a special device, which is applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve the problems of many reaction by-products, difficult recovery, low catalyst utilization rate, etc., and achieve yield and Effects of efficiency improvement, reduction of reaction by-products, and improvement of catalyst utilization

Active Publication Date: 2020-09-29
山东盛华电子新材料有限公司 +2
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Problems solved by technology

There are also certain shortcomings in this method, such as more reaction by-products, low catalyst utilization rate, difficult recovery, etc.

Method used

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  • Method and device for continuously producing sartan biphenyl
  • Method and device for continuously producing sartan biphenyl
  • Method and device for continuously producing sartan biphenyl

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Embodiment Construction

[0027] A method for continuous production of sartan biphenyl, using a fixed-bed reactor to carry out the continuous Grignard reaction of p-bromotoluene or p-chlorotoluene, and then using the obtained Grignard reagent in a fixed-bed reactor with a solid-loaded catalyst Carry out continuous coupling reaction with o-chlorobenzonitrile, and finally prepare sartan biphenyl, and the materials are added and output in a continuous manner during the reaction process after the whole production is started. The solid-supported catalyst spherical silica gel-supported unit Atomic Mn(0) and Zn(0) catalysts, wherein the coupling reaction is p-bromotoluene or p-chlorotoluene Grignard reagent and o-chlorobenzonitrile are pumped into the fixed bed to realize continuous reaction on the fixed reaction bed, p-bromotoluene Or p-chlorotoluene Grignard solution reacts with o-chlorobenzonitrile under the action of catalyst in the process of flowing on the reaction bed, by adjusting parameters such as fe...

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Abstract

The invention discloses a method and a device for continuously producing sartan biphenyl. The method comprises the following steps: carrying out continuous Grignard reaction on p-bromotoluene or p-chlorotoluene by adopting a fixed bed reactor; carrying out continuous coupling reaction on the obtained Grignard reagent and o-chlorobenzonitrile in a fixed bed reactor with a solid supported catalyst;finally, preparing the sartan biphenyl. Materials are added and output in a continuous manner in the whole reaction process after the production is started; the solid supported catalyst is spherical silica gel supported monoatomic Mn (0) and Zn (0) catalyst. The invention has the characteristics of continuous and stable production, timely transmission of reaction heat, no temperature runaway and deflagration problems, high reaction safety, reduction of reaction byproducts, and high product yield and efficiency.

Description

technical field [0001] The invention belongs to the technical field of continuous water-free, oxygen-free and air-isolated reaction equipment for chemical industry, and in particular relates to a continuous safety protection reaction device for solid-liquid phase strong exothermic reactions. Specifically relates to a method for preparing sartan biphenyl through continuous Grignard and coupling reactions. Background technique [0002] Sartan biphenyl, also known as 2-cyano-4'-methylbiphenyl, is mainly used in the production of sartan antihypertensive drugs and the application of other materials. It is a basic intermediate in the field of medicine and new materials. [0003] There are many synthetic methods for sartan biphenyl, the main synthetic methods are multi-step protective group method, aromatization ring-closure synthesis method, transition metal catalytic reduction method and Grignard coupling method. [0004] 1. Protective base multi-step method [0005] [0006...

Claims

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Application Information

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IPC IPC(8): C07C253/30C07C255/50C07F3/02
CPCC07C253/30C07F3/02C07C255/50Y02P20/584
Inventor 董兆恒武生喜冷英梅张慧勤王旭王德贤王少伟
Owner 山东盛华电子新材料有限公司
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