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Pharmaceutical composition for treatment and/or prevention of diseases, method and use thereof

A technology for drugs and diseases, applied in the field of IDO inhibitors, can solve the problems of low effective response rate, drug resistance, and poor single-use effect.

Active Publication Date: 2020-09-04
SICHUAN KELUN BIOTECH BIOPHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the diversity and mutation of tumor cell signaling pathways, the above-mentioned drugs have problems such as drug resistance, low effective response rate, and poor single-use effect in application.
The survival rate of patients treated with monotherapy is difficult to be significantly improved

Method used

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  • Pharmaceutical composition for treatment and/or prevention of diseases, method and use thereof
  • Pharmaceutical composition for treatment and/or prevention of diseases, method and use thereof
  • Pharmaceutical composition for treatment and/or prevention of diseases, method and use thereof

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Embodiment Construction

[0201] The present invention will be further described through the description of the accompanying drawings and embodiments below, but this is not a limitation of the present invention. Those skilled in the art can make various modifications or improvements according to the teaching of the present invention without departing from the basic idea and scope of the present invention.

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Abstract

The present invention relates to a pharmaceutical composition for treatment and / or prevention of diseases, use and a use thereof. Specifically, the invention relates to an application of an IDO (indoleamine 2, 3-dioxygenase) inhibitor containing a 1, 2, 5-oxadiazole structure to disease treatment and / or prevention in combination with other drugs. Specifically, the invention relates to a compound which can be used as an IDO inhibitor and contains a 1, 2, 5-oxadiazole structure, or an isomer, metabolite, stable isotope derivative, prodrug, pharmaceutically acceptable salt, hydrate, solvate, eutectic substance or polymorph thereof, and other drugs for combined medication. Compared with single medication, the combined medication has a good synergistic effect on abnormal cell proliferation diseases.

Description

technical field [0001] The invention relates to an IDO (indoleamine 2,3-dioxygenase) inhibitor containing a 1,2,5-oxadiazole structure used in combination with other drugs or used in combination for disease treatment and / or prevention. Specifically, the present invention relates to compounds containing 1,2,5-oxadiazole structures or their isomers, metabolites, stable isotope derivatives, prodrugs, pharmaceutically acceptable salts, hydrated Compounds, solvates, co-crystals or polymorphs are used in combination with other therapeutic drugs. Background technique [0002] Due to the unrestricted growth, invasion and metastasis of malignant tumors, the three conventional treatment methods (surgery, radiotherapy and chemotherapy) currently used in clinical practice cannot completely remove or completely kill tumor cells, and tumor cells can escape the body's immune system through various ways Therefore, tumor metastasis or recurrence often occurs. Tumor immunotherapy is to enha...

Claims

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Application Information

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IPC IPC(8): A61K31/4245A61K31/5377A61K31/454A61K31/496A61K45/06A61P35/00A61P35/02
CPCA61K31/4245A61K31/5377A61K31/454A61K31/496A61K45/06A61P35/00A61P35/02A61K2300/00
Inventor 王英李森林宋宏梅游泽金何云蔡家强田强薛彤彤王利春王晶翼
Owner SICHUAN KELUN BIOTECH BIOPHARMACEUTICAL CO LTD
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