Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Polypyrrole/manganese dioxide-methylene blue nano composite particle and preparation method thereof

A technology of nano-composite particles and manganese dioxide, which is applied in the direction of wave energy or particle radiation treatment materials, drug combinations, and pharmaceutical formulations, to achieve the effects of improving therapeutic effects, shortening reaction time, and strong operability

Active Publication Date: 2020-08-28
SHANXI UNIV
View PDF5 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, a polypyrrole / manganese dioxide nanocomposite particle is obtained by in-situ oxidation-reduction reaction with potassium permanganate as the inner core and reducing agent for a few minutes at room temperature, and the photosensitizer methylene blue is loaded to obtain polypyrrole / manganese dioxide nanocomposite particles Pyrrole / manganese dioxide-methylene blue nanocomposite particles used as photothermal and photodynamic combined therapy materials have never been reported

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Polypyrrole/manganese dioxide-methylene blue nano composite particle and preparation method thereof
  • Polypyrrole/manganese dioxide-methylene blue nano composite particle and preparation method thereof
  • Polypyrrole/manganese dioxide-methylene blue nano composite particle and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Preparation and characterization of polypyrrole / manganese dioxide-methylene blue nanocomposite particles:

[0045] (1) Dissolve 1.5g of polyvinyl alcohol 13000-23000 in 18mL of secondary water and stir at 80°C for 40 minutes; after the solution cools down to room temperature, add 1.25g of FeCl 3 ·6H 2 O, and stirred for 1 hour; then 135 μL of pyrrole monomer was added and stirred at 4°C for 4 hours; after the reaction, centrifuged and washed 5 times with hot secondary water to obtain polypyrrole nanoparticles, which were freeze-dried for later use.

[0046] figure 1 In order to use a transmission electron microscope to characterize the morphology of the obtained polypyrrole nanoparticles, the scale bar is 200 nm. The results show that the obtained polypyrrole nanomaterials are spherical, with good dispersion and an average size of 68.18nm.

[0047] figure 2 For the result of characterizing the obtained polypyrrole nanoparticles by X-ray photoelectron spectrometer, ...

Embodiment 2

[0057] Preparation and characterization of polypyrrole / manganese dioxide-methylene blue nanocomposite particles:

[0058] (1) Dissolve 1.6g of polyvinyl alcohol 13000-23000 in 20mL of secondary water, stir at 75°C for 50 minutes; after the solution cools down to room temperature, add 1.3g of FeCl 3 ·6H 2 0, balanced stirring for 1.5 hours; then add 140 μL of pyrrole monomer, and stir for 4.5 hours at 3°C; after the reaction, centrifuge and wash with hot secondary water for 4 times to obtain polypyrrole nanoparticles, which are freeze-dried for later use;

[0059] (2) Disperse 20 mg of polypyrrole nanoparticles prepared in step (1) in 8 mL of secondary water by ultrasonic dispersion, and set aside; dissolve 12.5 mg of potassium permanganate in 12 mL of secondary water, and add it dropwise to the above dispersed Stirring in the polypyrrole nanoparticles, reacting for 15 minutes, washing with secondary water and absolute ethanol three times alternately, and drying to obtain poly...

Embodiment 3

[0063] Preparation and characterization of polypyrrole / manganese dioxide-methylene blue nanocomposite particles:

[0064] (1) Dissolve 1.55g of polyvinyl alcohol 13000-23000 in 19mL of secondary water and stir at 70°C for 45 minutes; after the solution has cooled to room temperature, add 1.2g of FeCl 3 ·6H 2 O, and stirred for 1 hour; then added 138 μL of pyrrole monomer, and stirred for 3.5 hours at 5° C.; after the reaction, centrifuged, and washed with hot secondary water for 3 times to obtain polypyrrole nanoparticles, freeze-dried for later use;

[0065] (2) Disperse 17 mg of polypyrrole nanoparticles prepared in step (1) in 8 mL of secondary water by ultrasonic dispersion and set aside; dissolve 5 mg of potassium permanganate in 12 mL of secondary water and add dropwise to the dispersed polypyrrole nanoparticles. Stirring in the pyrrole nanoparticles, reacting for 5 minutes, washing with secondary water and absolute ethanol four times alternately, and drying to obtain p...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
sizeaaaaaaaaaa
sizeaaaaaaaaaa
Login to View More

Abstract

The invention discloses a polypyrrole / manganese dioxide-methylene blue nano composite particle and a preparation method thereof, and belongs to the technical field of nano composite materials. According to the preparation method, polypyrrole / manganese dioxide nano composite particles are directly prepared through in-situ oxidation-reduction reaction of a polypyrrole core and potassium permanganate, and the polypyrrole / manganese dioxide-methylene blue nano composite particles with the particle size of 69-72 nm are finally obtained after loading of a photosensitizer methylene blue. The nano composite particle has good photo-thermal conversion capability and singlet oxygen generation performance, and has good killing capability on cancer cells under laser radiation, it is indicated that the nano composite particle can be used as an effective photo-thermal and photodynamic combined treatment material. According to the preparation method, the polypyrrole / manganese dioxide nano composite particles are prepared by directly mixing the polypyrrole nano particles with potassium permanganate and quickly reacting, a reducing agent does not need to be additionally added in the process, use of alarge instrument is avoided, and the method is simple and easy to operate, quick in reaction and environmentally friendly.

Description

technical field [0001] The invention relates to a nanocomposite material, in particular to a polypyrrole / manganese dioxide-methylene blue nanocomposite particle and a preparation method and application thereof. Background technique [0002] Currently, cancer remains one of the deadliest diseases, killing millions of people every year. The development of nanomedicine can improve cancer treatment indicators and reduce side effects, opening up a new way for cancer treatment. Chemotherapy and radiation therapy are still the two most important clinical treatment methods at present, but both of them are prone to cause severe systemic toxicity and adverse reactions. In contrast, photothermal therapy and photodynamic therapy have attracted attention because of their specific spatiotemporal selectivity, less trauma, less side effects, negligible drug resistance, and faster healing. [0003] Various nanomaterials have been used in photothermal therapy, such as gold nanomaterials, co...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/14A61P35/00
CPCA61K9/14A61K41/0052A61K41/0057A61P35/00A61K2300/00
Inventor 李贝王琦沈腊珍董川双少敏
Owner SHANXI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com