Traditional Chinese medicine composition and application thereof for preventing and treating neonatal piglet diarrhea by taking medicine for sows
A new-born piglet and composition technology, which is applied in the directions of drug combination, medical preparations containing active ingredients, and pharmaceutical formulations, can solve the problems affecting the disease defense ability and later growth of newborn piglets, and achieve the function of anti-tumor immune system. , Improve the body's immune system function, the effect of high medicinal value
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Embodiment 1
[0025] The preparation of embodiment 1 composition 1
[0026] According to the proportion of the prescription, weigh 10-20 parts of Bupleurum bupleurum, 10-20 parts of honeysuckle, 8-15 parts of astragalus polysaccharide, 10-20 parts of Houttuynia cordata, and 10-20 parts of forsythia. After cleaning and removing impurities, add 8- Purified water with 10 times the weight of medicinal materials, decocted 2-3 times, 1 hour each time, filtered and combined the filtrate, concentrated into a thick paste with a relative density of 1.32-1.35 (50-55°C) by conventional methods, and added appropriate amount of auxiliary materials, Such as soluble starch, sucrose powder, etc., and dry to obtain powder.
Embodiment 2
[0027] The preparation of embodiment 2 composition 2
[0028] According to the proportion of the prescription, weigh 5-15 parts of Bupleurum, 5-15 parts of honeysuckle, 5-15 parts of astragalus polysaccharide, 5-15 parts of Houttuynia cordata, 5-15 parts of forsythia, after cleaning and removing impurities, add 8- Purified water 10 times the weight of medicinal materials, decocted 2-3 times, 1 hour each time, filtered and combined the filtrate. Add 2 times the volume of filtrate water for injection (V:V=1:2), filter through a 0.45μm organic filter to obtain the filtrate; then sterilize the filtrate at 121°C and 0.15Mpa for 20min to obtain the aqueous solution.
[0029] Under sterile conditions, porcine IFN-γ is added to the aqueous preparation at a weight ratio of 20-200 μg / g to obtain composition 2.
Embodiment 3
[0030] Embodiment 3 composition clinical trial research
[0031] 3.1 Test traditional Chinese medicine composition:
[0032]
[0033]
[0034] 3.2 Test location: A large-scale pig farm in Zhejiang, with 1,000 sows in stock. Before the test, piglets in the farrowing room of the pig farm had unexplained diarrhea. Conventional treatment (such as antibiotic therapy and oral rehydration salts, etc.) had no obvious Effect.
[0035]3.3 Test animals: select 83 newborn sows with similar parity, body weight, age and delivery period, and divide them into 8 groups at random, which are respectively Chinese medicine composition of the present invention and a control group. The selected sows had the same immunization procedures, and the feeding and management conditions were the same during pregnancy and postpartum, and they were all kept in a single stall.
[0036] 3.4 Test plan
[0037] 3.4.1 Treatment plan: Composition 1 is administered orally by mixed feeding, administered twice...
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