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γ-polyglutamic acid biological dressing and preparation method thereof

A technology of polyglutamic acid and biological dressings, applied in the field of medicine, which can solve the problems of slow absorption, complex ingredients, and high cost

Active Publication Date: 2021-12-07
海南芬森医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although medical dressings for treating burns can achieve their expected functions, they also have some limitations, such as slow absorption, poor air permeability, complex ingredients, high cost, etc., and the most important thing is that they cannot relieve the itching of wound healing during the treatment process. stabbing pain

Method used

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  • γ-polyglutamic acid biological dressing and preparation method thereof
  • γ-polyglutamic acid biological dressing and preparation method thereof
  • γ-polyglutamic acid biological dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The preparation of embodiment 1 gamma-polyglutamic acid biological dressing

[0033] composition:

[0034] γ-PGA 500g, low molecular weight hyaluronic acid 30g, oligomeric hyaluronic acid 6g, epidermal growth factor 0.5g, keratinocyte growth factor 0.3g, glycerin 140g, hydroxyethyl cellulose 40g, phenoxyethanol 30g and water 9253.2g , wherein, said Mr is the relative molecular weight; the molecular weight of γ-PGA is 200,000, the molecular weight of low molecular weight hyaluronic acid is 200,000, and the molecular weight of oligomeric hyaluronic acid is 5,000.

[0035] preparation:

[0036] 1) Mix γ-polyglutamic acid and 950g water, stir and dissolve to obtain liquid A;

[0037] 2) Mix and stir epidermal growth factor, keratinocyte growth factor, glycerin and 903.2 g of water to obtain liquid B;

[0038] 3) Mix low-molecular-weight hyaluronic acid, oligomeric hyaluronic acid, hydroxyethylcellulose, phenoxyethanol and 7400 g of water, and stir evenly to obtain liquid...

Embodiment 2

[0041] The preparation of embodiment 2 gamma-polyglutamic acid biological dressing

[0042] composition:

[0043] γ-PGA 500g, low molecular weight hyaluronic acid 30g, oligomeric hyaluronic acid 6g, epidermal growth factor 0.5g, keratinocyte growth factor 0.3g, glycerin 140g, hydroxyethyl cellulose 40g, yeast polypeptide 150g, alginate 40g , chitosan 30g, phenoxyethanol 30g and water 9033.2g, wherein, described Mr is relative molecular weight; The molecular weight is 5000.

[0044] preparation:

[0045] 1) Mix γ-polyglutamic acid and 920g water, stir and dissolve to obtain liquid A;

[0046] 2) Mix and stir epidermal growth factor, keratinocyte growth factor, yeast polypeptide, glycerin and 913.2 g of water to obtain liquid B;

[0047] 3) Mix low-molecular-weight hyaluronic acid, oligomeric hyaluronic acid, hydroxyethyl cellulose, alginate, chitosan, phenoxyethanol and 7200 g of water, and stir evenly to obtain liquid C;

[0048] 4) Mix liquid A, liquid B and liquid C uni...

Embodiment 3

[0050] The preparation of embodiment 3 gamma-polyglutamic acid biological dressing

[0051] composition:

[0052] γ-PGA 100g, low molecular weight hyaluronic acid 1g, oligomeric hyaluronic acid 0.1g, epidermal growth factor 0.01g, keratinocyte growth factor 0.05g, glycerin 20g, hydroxyethyl cellulose 5g, yeast polypeptide 5g, alginate 2g, chitosan 5g, phenoxyethanol 5g and water 856.84g, wherein, described Mr is relative molecular weight; The molecular weight of the acid is 5000.

[0053] preparation:

[0054] 1) Mix γ-polyglutamic acid and 105g water, stir and dissolve to obtain liquid A;

[0055] 2) Mix and stir epidermal growth factor, keratinocyte growth factor, yeast polypeptide, glycerin and 86.84 g of water to obtain liquid B;

[0056] 3) Low molecular weight hyaluronic acid, oligomeric hyaluronic acid, hydroxyethyl cellulose, alginate, chitosan, phenoxyethanol and 665g of water were mixed and stirred evenly to obtain liquid C;

[0057] 4) Mix liquid A, liquid B an...

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Abstract

The invention relates to the field of medicine, in particular to a γ-polyglutamic acid biological dressing and a preparation method thereof. The gamma-polyglutamic acid biological dressing includes packaging materials, substrates and dressing agents, and the dressing agents include the following raw materials: 200,000≤Mr<2 million gamma-polyglutamic acid, 10,000≤Mr<200,000 low molecular weight hyaluronic acid, oligomeric hyaluronic acid with Mr<10,000, epidermal growth factor, keratinocyte growth factor, glycerin, hydroxyethyl cellulose, phenoxyethanol and water; wherein the Mr is a relative molecular weight. The biological dressing of the present invention has stronger healing-promoting effect, and can significantly improve the healing quality, reduce pigmentation in the process of wound healing, relieve itching and tingling in the process of wound healing, and achieve a better effect of treating burns.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a gamma-polyglutamic acid biological dressing and a preparation method thereof. Background technique [0002] Skin damage is a common disease in clinical surgery, dermatology and other departments; there are many reasons for skin damage, such as various physical traumas such as surgery, burns, and some skin diseases can cause skin damage. For these skin injuries; in many cases, self-healing cannot be achieved only through self-healing of the wound, and medical intervention is required to assist, and medical dressings are the most commonly used medical intervention for skin injuries. There are various types of medical dressings in the prior art, and they have different effects, such as treating burns, acne, bed sores, repairing tissue wounds, and promoting absorption. In terms of treating burns, Chinese patent CN105169455A discloses a first-aid medical dressing for external use on burns a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/26A61L15/28A61L15/32A61L15/10A61L15/42A61L15/44
CPCA61L15/10A61L15/26A61L15/28A61L15/32A61L15/42A61L15/44A61L2300/214A61L2300/236A61L2300/252A61L2300/402A61L2300/404A61L2300/412A61L2300/602C08L77/04C08L5/08C08L89/00C08L1/284C08L5/04
Inventor 沈静飞杨欢胡小军王献标陈洁勤
Owner 海南芬森医疗器械有限公司
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