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Gamma-polyglutamic acid biological dressing and preparation method thereof

A polyglutamic acid and biological dressing technology, applied in the field of medicine, can solve the problems of inability to relieve itching, stinging, complex components, poor air permeability, etc., and achieve the effects of reducing pigmentation, promoting healing, and treating scald well.

Active Publication Date: 2020-08-25
海南芬森医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although medical dressings for treating burns can achieve their expected functions, they also have some limitations, such as slow absorption, poor air permeability, complex ingredients, high cost, etc., and the most important thing is that they cannot relieve the itching of wound healing during the treatment process. stabbing pain

Method used

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  • Gamma-polyglutamic acid biological dressing and preparation method thereof
  • Gamma-polyglutamic acid biological dressing and preparation method thereof
  • Gamma-polyglutamic acid biological dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 Preparation of γ-polyglutamic acid biological dressing

[0033] composition:

[0034] γ-PGA 500g, low molecular weight hyaluronic acid 30g, oligomeric hyaluronic acid 6g, epidermal growth factor 0.5g, keratinocyte growth factor 0.3g, glycerin 140g, hydroxyethyl cellulose 40g, phenoxyethanol 30g and water 9253.2g , Wherein said Mr is the relative molecular weight; the molecular weight of γ-PGA is 200,000, the molecular weight of low molecular weight hyaluronic acid is 200,000, and the molecular weight of oligomeric hyaluronic acid is 5000.

[0035] preparation:

[0036] 1) Mix γ-polyglutamic acid and 950 g of water, stir and dissolve to obtain liquid A;

[0037] 2) Mix and stir epidermal growth factor, keratinocyte growth factor, glycerin and 903.2g of water to obtain liquid B;

[0038] 3) Low-molecular-weight hyaluronic acid, oligomeric hyaluronic acid, hydroxyethyl cellulose, phenoxyethanol and 7400g of water are mixed and stirred evenly to obtain liquid C;

[0039] 4) ...

Embodiment 2

[0041] Example 2 Preparation of γ-polyglutamic acid biological dressing

[0042] composition:

[0043] γ-PGA 500g, low molecular weight hyaluronic acid 30g, oligomeric hyaluronic acid 6g, epidermal growth factor 0.5g, keratinocyte growth factor 0.3g, glycerol 140g, hydroxyethyl cellulose 40g, yeast polypeptide 150g, alginate 40g , Chitosan 30g, phenoxyethanol 30g and water 9033.2g, where Mr is the relative molecular weight; the molecular weight of γ-PGA is 200,000, the molecular weight of low molecular weight hyaluronic acid is 200,000, and the molecular weight of oligomeric hyaluronic acid The molecular weight is 5000.

[0044] preparation:

[0045] 1) Mix γ-polyglutamic acid and 920 g of water, stir and dissolve to obtain liquid A;

[0046] 2) Mix and stir epidermal growth factor, keratinocyte growth factor, yeast polypeptide, glycerin and 913.2g of water to obtain liquid B;

[0047] 3) Low-molecular-weight hyaluronic acid, oligomeric hyaluronic acid, hydroxyethyl cellulose, alginate...

Embodiment 3

[0050] Example 3 Preparation of γ-polyglutamic acid biological dressing

[0051] composition:

[0052] γ-PGA 100g, low molecular weight hyaluronic acid 1g, oligomeric hyaluronic acid 0.1g, epidermal growth factor 0.01g, keratinocyte growth factor 0.05g, glycerol 20g, hydroxyethyl cellulose 5g, yeast polypeptide 5g, alginate 2g, 5g of chitosan, 5g of phenoxyethanol and 856.84g of water, where Mr is the relative molecular weight; the molecular weight of γ-PGA is 2 million, the molecular weight of low-molecular-weight hyaluronic acid is 50,000, and the oligomeric hyaluronic acid The molecular weight of the acid is 5,000.

[0053] preparation:

[0054] 1) Mix γ-polyglutamic acid and 105 g of water, stir and dissolve to obtain liquid A;

[0055] 2) Mix and stir epidermal growth factor, keratinocyte growth factor, yeast polypeptide, glycerin and 86.84g water to obtain liquid B;

[0056] 3) Low-molecular-weight hyaluronic acid, oligomeric hyaluronic acid, hydroxyethyl cellulose, alginate, chi...

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Abstract

The invention relates to the field of medicines, in particular to a gamma-polyglutamic acid biological dressing and a preparation method thereof. The gamma-polyglutamic acid biological dressing comprises a packing material, a base material and a dressing agent, wherein the dressing agent is prepared from the following raw materials of amma-polyglutamic acid with Mr being greater than or equal to 200,000 and less than 2 millions, low-molecular-weight hyaluronic acid with Mr being greater than or equal to 10,000 and less than 200,000, oligomeric hyaluronic acid, with Mr being less than 10,000, epidermal growth factor, keratinocyte growth factor, glycerol, hydroxyethyl cellulose, phenoxyethanol and water, wherein the Mr is a relative molecular weight. The biological dressing disclosed by theinvention has a stronger healing promoting effect, and can be used for remarkably improving the healing quality, reducing pigmentation in a wound healing process, relieving itching and stabbing pain in the wound healing process and realizing a better treatment and scalding effect.

Description

Technical field [0001] The invention relates to the field of medicine, in particular to a gamma-polyglutamic acid biological dressing and a preparation method thereof. Background technique [0002] Skin injury is a common disease in clinical surgery, dermatology and other departments; there are many reasons for skin injury, such as various physical traumas such as surgery, burns, and some skin diseases can cause skin damage. In response to these skin injuries; in many cases, self-healing cannot be achieved only through self-repair of wounds, and medical intervention is needed to assist, and medical dressings are the most commonly used medical intervention for skin injuries. There are many types of medical dressings in the prior art, and they have different effects, such as being used to treat burns, acne, bedsores, tissue wound repair, and absorption promotion. In the treatment of scalds, Chinese Patent CN105169455A discloses an external emergency medical dressing for burns and ...

Claims

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Application Information

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IPC IPC(8): A61L15/26A61L15/28A61L15/32A61L15/10A61L15/42A61L15/44
CPCA61L15/10A61L15/26A61L15/28A61L15/32A61L15/42A61L15/44A61L2300/214A61L2300/236A61L2300/252A61L2300/402A61L2300/404A61L2300/412A61L2300/602C08L77/04C08L5/08C08L89/00C08L1/284C08L5/04
Inventor 沈静飞杨欢胡小军王献标陈洁勤
Owner 海南芬森医疗器械有限公司
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