Tumor treatment composite nano material and preparation method thereof

A composite nanomaterial and tumor treatment technology, which is applied in the field of composite nanomaterials for tumor treatment and its preparation, can solve problems such as toxicity, and achieve the effects of less toxic and side effects, good safety and good sustained-release effect.

Inactive Publication Date: 2020-08-18
CHENGDU ZHIA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, it h...

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Embodiment 1

[0027]A composite nanomaterial for tumor treatment, characterized in that it is made of the following raw materials in parts by weight: 3 parts of silver sulfide quantum dots, 4 parts of silver selenide quantum dots, 1 part of hyperbranched polytetrahydrofuran, alkylene oxide 1 part of oxysilyl-modified bis(2-aminophenyl) disulfide.

[0028] The preparation method of the epoxy alkoxy silicon modified bis(2-aminophenyl) disulfide comprises the steps of: mixing epoxyalkylsiloxane, bis(2-aminophenyl) disulfide, hydrogen Sodium oxide was added to dimethyl sulfoxide, stirred and reacted at 75°C for 8 hours, then filtered to remove insoluble matter, and the solvent was removed by rotary evaporation to obtain epoxyalkoxy silicon-modified bis(2-aminophenyl) disulfide; The molar ratio of the epoxy-based alkyl siloxane, two (2-aminophenyl) disulfide, sodium hydroxide, and dimethyl sulfoxide is 2:1:0.4:10; the epoxy-based alkyl silicon The oxane is 2-(3,4-epoxycyclohexyl)ethyltriethoxys...

Embodiment 2

[0032] A composite nanomaterial for tumor treatment, characterized in that it is made of the following raw materials in parts by weight: 3.5 parts of silver sulfide quantum dots, 4.5 parts of silver selenide quantum dots, 1.2 parts of hyperbranched polytetrahydrofuran, alkylene oxide 1.2 parts of oxysilyl-modified bis(2-aminophenyl) disulfide.

[0033] The preparation method of the epoxy alkoxy silicon modified bis(2-aminophenyl) disulfide comprises the steps of: mixing epoxyalkylsiloxane, bis(2-aminophenyl) disulfide, carbonic acid Sodium was added to N,N-dimethylformamide, stirred and reacted at 78°C for 9 hours, then filtered to remove insoluble matter, and the solvent was removed by rotary evaporation to obtain epoxyalkoxy silicon modified bis(2-aminophenyl ) disulfide; the molar ratio of the epoxy group alkyl siloxane, two (2-aminophenyl) disulfide, sodium carbonate, N,N-dimethylformamide is 2:1:0.5:11; The epoxyalkylsiloxane is trimethoxy[2-(7-oxabicyclo[4.1.0]hept-3-yl...

Embodiment 3

[0037] A composite nanomaterial for tumor treatment, characterized in that it is made of the following raw materials in parts by weight: 4 parts of silver sulfide quantum dots, 5 parts of silver selenide quantum dots, 1.5 parts of hyperbranched polytetrahydrofuran, alkylene oxide 1.5 parts of oxysilyl-modified bis(2-aminophenyl) disulfide.

[0038] The preparation method of the epoxy alkoxy silicon modified bis(2-aminophenyl) disulfide comprises the steps of: mixing epoxyalkylsiloxane, bis(2-aminophenyl) disulfide, hydrogen Potassium oxide was added to N,N-dimethylacetamide, stirred and reacted at 80°C for 10 hours, then filtered to remove insoluble matter, and the solvent was removed by rotary evaporation to obtain epoxy alkoxy silicon modified bis(2-aminobenzene base) disulfide; the mol ratio of the epoxy group alkyl siloxane, two (2-aminophenyl) disulfide, potassium hydroxide, N,N-dimethylacetamide is 2:1:0.6: 15; the epoxyalkylsiloxane is 5,6-epoxyhexyltriethoxysilane.

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Abstract

The invention discloses a tumor treatment composite nano material which is characterized by being prepared from the following raw materials in parts by weight: 3-5 parts of silver sulfide quantum dots, 4-6 parts of silver selenide quantum dots, 1-2 parts of hyperbranched polytetrahydrofuran and 1-2 parts of epoxy alkoxy silicon modified bis (2-aminophenyl) disulfide. The invention also discloses apreparation method of the tumor treatment composite nano material. The tumor treatment composite nano material disclosed by the invention has the characteristics of good stability, long in-vivo circulation time, small toxic and side effects and the like, has a good drug slow release effect, has good selectivity on tumor cells, and does not have obvious systemic toxicity.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a composite nanomaterial for tumor treatment and a preparation method thereof. Background technique [0002] Chemoradiotherapy is the main method for clinical treatment of cancer, especially advanced cancer, and is an effective systemic treatment. However, the traditional chemoradiotherapy drugs and administration methods have the disadvantages of non-specific recognition of chemoradiotherapy drugs, which can easily damage normal cells and tissues, and even cause systemic poisoning. Moreover, the efficiency of drug uptake by tumor cells is low, and repeated administration can easily cause tumors. Cells develop drug resistance and other shortcomings. [0003] In recent years, nano drug carriers have been widely used in the selective delivery of anticancer drugs due to their long blood circulation time and high passive tumor targeting efficiency. At present, the nano-dr...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K47/60A61P35/00A61K49/00
CPCA61K41/0057A61K47/60A61K49/0019A61K49/0054A61P35/00
Inventor 向兴力
Owner CHENGDU ZHIA TECH CO LTD
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