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Application of pyr3 in the preparation of drugs for protecting liver damage

A technology for liver damage, chemical liver damage, applied in the field of medicine

Active Publication Date: 2021-07-06
THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the therapeutic effect of Pyr3 or its analogues on liver injury has not been reported before.

Method used

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  • Application of pyr3 in the preparation of drugs for protecting liver damage
  • Application of pyr3 in the preparation of drugs for protecting liver damage
  • Application of pyr3 in the preparation of drugs for protecting liver damage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0038] Build using CCl 4 Induced hepatic fibrosis model in C57 mice on an all-wild-type background. Six-week-old C57 mice were intraperitoneally injected with carbon tetrachloride (CCl4)-olive oil (1:4) (hereinafter referred to as CCl4) at 5 ml / kg body weight. 4 ), twice a week for 8 weeks; C57 mice were randomly divided into Pyr3 (TRPC3 inhibitor) group and DMSO control group at the 7th week from the beginning of modeling. The mice in the Pyr3 (inhibitor) group were injected intraperitoneally with 10 mg / kg of Pyr3 for 2 weeks, twice a week; for 2 weeks, twice a week; at the same time, the mice in the DMSO control group were injected with the same volume of DMSO solvent. 48 hours after the last injection, the mice were anesthetized and sacrificed and blood and liver samples were collected. (Note: DMSO is an organic solvent for dissolving Pyr3.)

[0039] After collecting mouse liver paraffin-embedded sections, H&E staining (Solarbie, Beijing, China, Ca#G1340), Sirius Red Sta...

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Abstract

The invention relates to the technical field of medicine, in particular to the application of Pyr3 in the preparation of drugs for protecting liver damage. The present invention proves through experiments that Pyr3 can inhibit the level changes of ALT, AST, HA, Collagen I and / or α-SMA, improve liver fibrosis, liver steatosis, liver cell necrosis, inflammatory cell infiltration, connective tissue hyperplasia and / or Or hepatic lobular structural disorder, compared with the control group, Pyr3 has a significant protective effect on liver tissue. Therefore, the present invention provides the application of Pyr3 in the preparation of medicine for treating fibrosis, and provides a medicine for protecting liver damage containing Pyr3.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of Pyr3 in the preparation of drugs for protecting liver damage. Background technique [0002] Hepatic fibrosis is a pathological process in which the liver undergoes self-repair after various chronic injuries or inflammatory stimuli. It is mainly manifested in the activation of hepatic stellate cells and the abnormal accumulation of extracellular matrix (ECM) components. It plays a key role in the occurrence and development of liver fibrosis. Activated hepatic stellate cells undergo differentiation and metastasis, thereby promoting cell proliferation, migration, contraction, and ECM synthesis and deposition, leading to scar formation and eventually liver cirrhosis or even liver cancer. [0003] The molecular mechanism of liver fibrosis is extremely complex. Ursodeoxycholic acid (Ursodeoxycholic Acid, UDCA) is currently the only FDA-approved effective drug for th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/415A61P1/16
CPCA61K31/415A61P1/16
Inventor 徐迅迪
Owner THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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