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Pharmaceutical composition for preventing and treating myocardial ischemia and preparation method thereof

A technology of myocardial ischemia and composition, applied in the field of medicine, to achieve the effect of improving myocardial cell necrosis, reducing the degree of myocardial injury, and broad clinical application prospects

Inactive Publication Date: 2016-07-13
FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, so far, there has been no report on the combination of Danshen and Shichangpu for the prevention and treatment of myocardial ischemia

Method used

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  • Pharmaceutical composition for preventing and treating myocardial ischemia and preparation method thereof
  • Pharmaceutical composition for preventing and treating myocardial ischemia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation of embodiment 1 pharmaceutical composition of the present invention

[0024] Weigh the raw materials according to the following ratio:

[0025] Danshen 10g, Shichangpu 10g.

[0026] The preparation method is as follows:

[0027] Add 8 times the volume of raw materials into water and soak for 1 hour, soak for 1 hour, decoct in water for 1 hour, extract twice in total, filter, combine the filtrate, concentrate under reduced pressure to a thick paste, dry under reduced pressure for 10 hours, and pulverize to obtain the pharmaceutical combination of the present invention 3.4g.

Embodiment 2

[0028] The preparation of embodiment 2 pharmaceutical compositions of the present invention

[0029] Weigh the raw materials according to the following ratio:

[0030] Danshen 15g, Shichangpu 15g.

[0031] The preparation method is as follows:

[0032] Add 8 times the raw material to water and soak for 1 hour, soak for 1 hour, decoct in water for 1 hour, extract twice in total, filter, combine the filtrate, concentrate under reduced pressure to a thick paste, dry under reduced pressure for 10 hours, and pulverize to obtain the pharmaceutical composition 5.4 of the present invention. g.

Embodiment 3

[0033] The preparation of embodiment 3 pharmaceutical composition of the present invention

[0034] Weigh the raw materials according to the following ratio:

[0035] Danshen 30g, Shichangpu 30g.

[0036] The preparation method is as follows:

[0037] Add 8 times of water to the raw material and soak for 1 hour, soak for 1 hour, decoct in water for 1 hour, extract twice in total, filter, combine the filtrate, concentrate under reduced pressure to a thick paste, dry under reduced pressure for 10 hours, and pulverize to obtain the pharmaceutical composition of the present invention 9.0 g.

[0038] The beneficial effect of the present invention is proved by the following drug efficacy experiments, wherein the Xinxin Dan is the pharmaceutical composition of the present invention prepared according to Example 1.

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PUM

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Abstract

The invention discloses a pharmaceutical composition for preventing and treating myocardial ischemia, prepared from the following medicinal materials according to parts by weight: 10-30 parts of Radix Salviae Miltiorrhizae and 10-30 parts of Rhizoma Acori Graminei.Pharmacological experiments show that the pharmaceutical composition is capable of inhibiting electrocardiogram ST segment value rise due to myocardial ischemia and significantly improving myocardial cell necrosis and myocardial fribrinolysis and alleviating myocardial injury degree, and also show that two herbs in the composition are synergistic under specific usage ratio, providing significant prevention and treatment of myocardial ischemia.The pharmaceutical composition has a wide source range of raw materials and low cost, the preparation process is simple, and the composition has clear efficacy without toxic and side effect and has a promising clinical application prospect.

Description

technical field [0001] The invention relates to a pharmaceutical composition for preventing and treating myocardial ischemia and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Myocardial ischemia refers to a pathological state in which the blood perfusion of the heart is reduced, resulting in reduced oxygen supply to the heart, abnormal myocardial energy metabolism, and failure to support the normal work of the heart. There are many reasons that can cause myocardial ischemia, the most common of which is coronary atherosclerosis, followed by inflammation, spasm, embolism, connective tissue diseases, trauma and congenital malformations. With the improvement of living standards, the prevalence of myocardial ischemia in my country is increasing year by year. It has become a common and frequently-occurring disease in middle-aged and elderly people. It is prone to secondary myocardial infarction and sudden death, seriously affecting...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/888A61P9/10A61K36/537
CPCA61K36/537A61K36/888A61K2236/331A61K2236/39A61K2300/00
Inventor 彭军褚剑锋林珊沈阿灵符彩选陈宏伟
Owner FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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