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Liposome disinfection gel and preparation method thereof

A technology for disinfecting gel and liposomes, applied in the directions of liposome delivery, liquid delivery, pharmaceutical formulations, etc., can solve the problems of scarring and easy to produce inflammation, so as to protect the wound surface, improve the rough and chapped skin, and improve the sterilization effect. Effect

Inactive Publication Date: 2020-07-17
GUIZHOU YANGSHENG MEDICAL INSTR
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is: to solve the problem that using the existing skin disinfectant to sterilize superficial wounds is easy to produce inflammation and even make scars after the wound heals, and it is impossible to avoid contamination of the wound by the outside world after disinfection. A kind of liposome antiseptic gel and preparation method thereof

Method used

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  • Liposome disinfection gel and preparation method thereof
  • Liposome disinfection gel and preparation method thereof
  • Liposome disinfection gel and preparation method thereof

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Embodiment 1

[0035] The present embodiment provides a kind of liposome antiseptic gel and preparation method thereof, each component of liposome antiseptic gel and its weight are: bactericide 80g, soybean lecithin 12g, carboxylated chitosan 3g, cholesterol 4g, Glycerin 20g, sodium starch glycolate 70g, sodium alginate 50g, amino acid 2.73g, vitamin E 6g, purified water 900ml. Among them, the composition and weight of the fungicide are: polyhexamethylene biguanide hydrochloride 55g, chlorphenesin 15g, phenoxyethanol 10g, the composition and weight of the amino acid are: L-leucine 1.15g , 0.74g of valine, 0.64g of isoleucine, and 0.2g of DL-methionine. Among the components of the bactericide, polyhexamethylene biguanide hydrochloride has the strongest bactericidal effect and has the effect of killing viruses, so it has the highest content among the components of the selected bactericide. Because L-leucine, valine, isoleucine, and DL-methionine have better solubility than other neutral amino...

Embodiment 2

[0048] The components of liposome disinfection gel and their weight are: 40g of fungicide, 13g of soybean lecithin, 9g of carboxylated chitosan, 6g of cholesterol, 50g of glycerin, 130g of sodium starch glycolate, 60g of sodium alginate, 6.05g of amino acid, Vitamin E 9g, purified water 680ml. Among them, the composition and weight of the fungicide are: 20g of chlorhexidine acetate, 5g of benzalkonium chloride, and 15g of phenoxyethanol; the composition and weight of the amino acid are: 3.97g of L-valine, 3.97g of isoleucine 0.46g, DL-methionine 1.62g.

[0049] Liposome disinfection gel preparation method: in steps 1 and 3, the duration of ultrasonication and stirring by ultrasonic extraction machine is 30 minutes and 15 minutes respectively; in step 4, the duration of stirring by ultrasonic extraction machine is 13 minutes; step In 6, the duration of stirring and emulsifying for the first time and the second time using the ultrasonic extractor is 90 minutes and 40 minutes re...

Embodiment 3

[0052] The components of liposome disinfection gel and their weight are: 20g of fungicide, 12g of soybean lecithin, 6g of carboxylated chitosan, 5g of cholesterol, 80g of glycerin, 50g of sodium carboxymethyl starch, 75g of sodium alginate, 2.05g of amino acid, Vitamin E 4g, purified water 745ml. Among them, the composition and weight of the fungicide are: 16g of chlorhexidine acetate and 4g of benzalkonium chloride, and the composition and weight of the amino acid are: 1.73g of L-leucine and 0.32g of isoleucine.

[0053] Liposome disinfection gel preparation method: in steps 1 and 3, the duration of ultrasonication and stirring by ultrasonic extraction machine is 50 minutes and 20 minutes respectively; in step 4, the duration of stirring by ultrasonic extraction machine is 15 minutes; step In 6, the duration of stirring and emulsifying for the first time and the second time using the ultrasonic extractor is 100 minutes and 30 minutes respectively; 145ml.

[0054] The liposo...

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Abstract

The invention discloses liposome disinfection gel and a preparation method thereof, and relates to the technical fields of antibiosis and disinfection. The lipidosome disinfection gel is composed of the following components in parts by weight: 1.0 to 20.0 parts of a bactericide, 0.5 to 1.5 parts of soybean phospholipid, 0.1 to 1.0 part of carboxylated chitosan, 0.1 to 1.0 part of cholesterol, 1.0to 10.0 parts of glycerol, 5.0 to 15.0 parts of carboxymethyl starch sodium, 2.0 to 10.0 parts of sodium alginate, 0.1 to 1.0 part of amino acid, 0.2 to 1.0 part of vitamin E and 39.5 to 90.0 parts ofpurified water. The bactericide disclosed by the invention is prepared from various different non-irritant substances, the bactericide is encapsulated by a liposome technology, the effect of bactericide is released by virtue of the contact effect of lipidosome; the skin disinfectant is used as a carrier, so that effective components can quickly and accurately reach an acting part, quick sterilization and long-acting bacteriostasis are realized, and the problems that inflammation is easily generated and even scars are formed after the wound is healed when an existing skin disinfectant is usedfor disinfecting the superficial wound and the wound cannot be prevented from being polluted by the outside after disinfection are solved by utilizing a physical film forming principle.

Description

technical field [0001] The invention relates to the technical field of antibacterial disinfection, in particular to a liposome disinfection gel and a preparation method thereof. Background technique [0002] The skin and mucous membranes are important defense organs of the human body, and are the most important barrier for the human body to resist the invasion of external biological and physical and chemical factors. The skin and mucous membranes are in direct contact with the outside world, especially when hands are in contact with various items, and will be invaded by various pollution and harmful factors. Therefore, it is very important to take effective skin and mucous membrane disinfection measures to prevent the epidemic and control the spread of infection, and to maintain the health of oneself and others. [0003] There are many types of skin disinfectants on the market now. Common skin disinfectants include ethanol, biguanides, quaternary ammonium salts, povidone-io...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K9/06A61K31/785A61K31/155A61K31/14A61K31/085A61K31/055A61K47/24A61K47/28A61K47/10A61K47/18A61K47/22A61P17/00A61P31/02A61P17/02
CPCA61K9/0014A61K9/06A61K9/127A61K9/1277A61K31/055A61K31/085A61K31/14A61K31/155A61K31/785A61K47/10A61K47/183A61K47/22A61K47/24A61K47/28A61K47/36A61P17/00A61P17/02A61P31/02A61K2300/00
Inventor 黄昌平郑茂鑫田静吴丹李荣恒姚关花
Owner GUIZHOU YANGSHENG MEDICAL INSTR
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