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Conductive microneedle paster for wound repairing and preparation method of conductive microneedle paster

A technology of wound repair and microneedle sticking, applied in the direction of electrotherapy, electrodes, wound clips, etc., can solve the problems that the treatment effect needs to be improved, and achieve the effect of promoting wound repair, regulating cell proliferation and differentiation, and preventing re-cracking

Active Publication Date: 2020-07-14
NANJING DRUM TOWER HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Common wound repair methods include suturing, fixing with bandages, and using medical dressings, etc. These methods passively treat wounds through the interaction of drugs, dressings, and wounds, without involving the regulation of endogenous cell behavior. Treatment effect needs to be improved

Method used

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  • Conductive microneedle paster for wound repairing and preparation method of conductive microneedle paster
  • Conductive microneedle paster for wound repairing and preparation method of conductive microneedle paster
  • Conductive microneedle paster for wound repairing and preparation method of conductive microneedle paster

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preparation example Construction

[0029] The invention provides a preparation method for a conductive microneedle patch for wound repair, comprising the following steps:

[0030] 1) Preparation of conductive microneedle unit 1: Fully fill the microneedle raw material solution into the lower template 1-1 with inclined needle-shaped holes 1-11 by vacuum or centrifugation, and the cover has "E"-shaped protrusions 1- The upper template 1-2 of 21, after the microneedle raw material solution is solidified, remove the upper template 1-2, press the "E" shaped guide rail 1-3 on the surface of the microneedle, and pour the conductive solution into the "E" shaped guide rail 1-3 On the top, one end of the wire 1-4 is inserted into the conductive solution, and then the microneedle raw material solution is perfused, and after the microneedle raw material solution is solidified, it is peeled off from the lower template 1-1 to obtain a conductive microneedle unit;

[0031] 2) Preparation of conductive microneedle patches: Sel...

Embodiment 1

[0043] A conductive microneedle patch using liquid metal as a conductive solution, prepared according to the following method:

[0044] (1) Configure microneedle raw material solution and conductive solution

[0045] Microneedle raw material solution: Prepare a mixed solution containing polyethylene glycol diacrylate with a mass fraction of 50% and polyethylene glycol methyl methacrylate with a mass fraction of 20% as the microneedle raw material solution, and place it in the dark ; Add 1% 2-hydroxyl-2-methylpropiophenone as the microneedle raw material solution to form a microneedle raw material solution to be cured, and the microneedle raw material solution to be cured is polymerized under ultraviolet light to make the microneedles Solidification of the raw material solution;

[0046] Conductive solution: choose liquid metal as the conductive solution and place it in the syringe.

[0047] (2) Preparation of conductive microneedle unit 1 with needle tip 1-5 inclined to the ...

Embodiment 2

[0054] A conductive microneedle patch using a multi-walled carbon nanotube dispersion as a conductive solution, prepared according to the following method:

[0055] (1) Configure microneedle raw material solution and conductive solution

[0056] Microneedle raw material solution: configure a mixed solution containing 10% hyaluronic acid by mass fraction and 30% methacrylate gelatin as the microneedle raw material solution, and place it in the dark; 2-hydroxyl-2-methylpropiophenone with a volume fraction of 1% is added to the solution to form a microneedle raw material solution to be cured, and the microneedle raw material solution to be cured is polymerized under ultraviolet light to cure the microneedle raw material solution;

[0057] Conductive solution: a multi-walled carbon nanotube dispersion with a mass fraction of 8% was selected as the conductive solution and placed in a syringe.

[0058] (2) Preparation of conductive microneedle unit 1 with needle tip 1-5 inclined to...

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Abstract

The invention discloses a conductive microneedle paster for wound repairing and a preparation method of the conductive microneedle paster. According to the method, through multi-template copying and solidification at different steps, conductive microneedle units which are provided with inclined needle tips and are wrapped by "E-shaped" guide tracks are prepared, two conductive microneedle units with needle tips opposite to each other are connected with a gauze at an interval, and are respectively connected with a power supply anode and a power supply cathode through leads fixed in the "E-shaped" guide tracks, and then the buckle-shaped conductive microneedle paster is prepared. The conductive microneedle paster disclosed by the invention can be adhered to a wound, the buckle-shaped needletips are beneficial to shrinkage and fixation of the wound, when an external power supply is connected, a spatial electric field can be formed between two microneedle units, cell migration can be induced, cell proliferation and differentiation can be promoted, wound healing can be accelerated, and the conductive microneedle paster is diverse in function, remarkable in treatment effect and wide inapplicable range.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a conductive microneedle patch for wound repair and a preparation method thereof. Background technique [0002] Wounds frequently occur in daily life and surgical operations, and wound repair is a concern in the medical and health fields all over the world. Common methods of wound repair include suturing, fixing with bandages, and using medical dressings, etc. These methods passively treat wounds through the interaction of drugs, dressings, and wounds, without involving the regulation of endogenous cell behavior. The therapeutic effect needs to be improved. [0003] Response to electrical stimulation is a common phenomenon in organisms, for example, many cells undergo a series of changes in morphology, metabolism and behavior when exposed to an appropriate electric field. Taking advantage of this phenomenon, researchers have applied electrical stimulation to many c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/36C08L71/02C08L89/00C08L5/08C08J3/28A61B17/08A61N1/04
CPCA61B17/08A61N1/0464A61N1/0468A61N1/0492A61N1/36017C08J3/28C08J2371/02C08J2389/00C08J2405/08C08J2471/02
Inventor 赵远锦张筱萱王月桐
Owner NANJING DRUM TOWER HOSPITAL
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