Application of Jasurolignoside in production of medicine for treating and/or preventing lung injuries

A technology for lung injury and acute lung injury, applied in the field of medicine, can solve problems such as effective lung injury, and achieve the effects of relieving alveolar septum thickening, improving survival rate, and reducing pathological damage

Active Publication Date: 2020-07-10
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

No studies have shown that Jasurolignoside is effective in the treatment of lung injury

Method used

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  • Application of Jasurolignoside in production of medicine for treating and/or preventing lung injuries
  • Application of Jasurolignoside in production of medicine for treating and/or preventing lung injuries
  • Application of Jasurolignoside in production of medicine for treating and/or preventing lung injuries

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Embodiment Construction

[0029] The present invention will be further described in detail below in conjunction with the accompanying drawings, so that those skilled in the art can implement it with reference to the description.

[0030] It should be understood that terms such as "having", "comprising" and "including" as used herein do not entail the presence or addition of one or more other elements or combinations thereof.

[0031] It should be noted that the experimental methods described in the following embodiments, unless otherwise specified, are conventional methods, and the reagents and materials, unless otherwise specified, can be obtained from commercial sources.

[0032] 1. Materials

[0033] 1.1 Experimental animals

[0034] SPF grade healthy BALB / C mice, weighing 20-22g, 7-8 weeks old, male, were purchased from Hunan Slack Jingda Experimental Animal Co., Ltd. All experimental animals were raised in a controlled environment, room temperature 18-24°C, The humidity was 40%-50%. During the e...

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Abstract

The invention discloses application of Jasurolignoside in production of a medicine for treating and / or preventing lung injuries of mammals, including humans. A structural formula of the Jasurolignoside is shown in a formula (I) as shown in the description. According to application of the Jasurolignoside in production of the medicine for treating and / or preventing the lung injuries of the mammals,including the humans, the medicine has a certain effect of preventing the lung injuries, inhibits release of proinflammatory cytokines of the lungs, and inhibits TLR4 signal channels.

Description

technical field [0001] The invention relates to the technical field of medicine. More specifically, the present invention relates to the use of Jasurolignoside in the preparation of medicines for treating and / or preventing lung injury. Background technique [0002] In recent years, the morbidity and mortality of pneumonia have been increasing. At present, the commonly used drugs for the treatment of pneumonia include hormones and the following types of antibiotics: the first type is penicillins and first-generation cephalosporins, etc.; the second type is fluoroquinolones (moxifloxacin, gemifloxacin, and levofloxacin); The third category is macrolide drugs (erythromycin and azithromycin, etc.). In recent years, despite the application of powerful antibiotics and effective vaccines, the mortality rate of pneumonia has not decreased, but has increased. The reason is that the extensive use of antibiotics leads to the increase of multi-drug resistant pathogens, which leads to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P11/00A61P31/00
CPCA61K31/7048A61P11/00A61P31/00
Inventor 高红伟韩珊苑仁祎坤黄莉婷许琼明
Owner GUANGXI UNIV OF CHINESE MEDICINE
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