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Method for identifying disease-related miRNA and method for deducing enrichment signal pathway

A technology for signaling pathways and diseases, applied in the field of identification of disease-causing genes, which can solve the problems of incompleteness, inability of prediction tools to discover miRNAs, and difficulty in information.

Active Publication Date: 2020-07-07
XIAN UNIV OF TECH
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AI Technical Summary

Problems solved by technology

[0008](1) All of these machine learning methods require experimentally verified association information between miRNAs and diseases, which is very difficult or even impossible to obtain
[0009] (2) Some methods require miRNA targets and known genes associated with disease may be incomplete or inaccurate
[0011] (4) In the absence of known associated miRNAs, some predictive tools cannot be used to discover disease-associated miRNAs

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  • Method for identifying disease-related miRNA and method for deducing enrichment signal pathway
  • Method for identifying disease-related miRNA and method for deducing enrichment signal pathway
  • Method for identifying disease-related miRNA and method for deducing enrichment signal pathway

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Embodiment Construction

[0049] The present invention will be further elaborated below according to the drawings and specific embodiments.

[0050] The present invention is a method for inferring the enrichment signal pathway of disease-associated miRNA, specifically according to the following steps:

[0051] Step 1. Use the PRISMA process to collect data set A of a specific disease-related miRNA:

[0052] Such as figure 1 As shown, all the literatures of disease-related miRNAs were obtained from the three databases of Medline, PubMed, and Embase. After removing duplicate literatures, in the remaining literatures, review the titles and abstracts of the articles one by one to exclude inappropriate literatures, and then review The full text of the literature excludes inappropriate literature to obtain the required miRNA data set;

[0053] Inappropriate literature mentioned above includes literature not related to humans or mice, not related to a specific disease, case reports, and non-original researc...

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Abstract

The invention discloses a method for identifying a disease-related miRNA, and a method for deducing an enrichment signal pathway. The method comprises miRNA and disease related literature screening, coding protein gene and disease related literature screening, disease-related miRNA deducing, disease-related coding protein gene deducing, miRNA-gene regulating relation constructing, chi-square teststatistics calculation, Fisher accurate testing, etc. According to the method, a problem of identifying the disease-related miRNA is settled so that the result is more accurate and credible. A relation between an existing protein coding gene and the signal pathway is utilized for indirectly constructing an association relation between the miRNA and the signal pathway, thereby determining a biological function of the miRNA in a disease.

Description

technical field [0001] The invention belongs to the field of identifying disease-causing genes, and specifically relates to a method for identifying disease-related miRNAs, and also relates to a method for inferring the above-mentioned disease-related miRNA enrichment signal pathway. Background technique [0002] Complex diseases are often caused by multiple factors, such as genetic variation, SNP (single nucleotide polymorphism), copy number variation, epigenetic variation, etc. Among the many pathogenic factors, the role played by non-coding RNA cannot be underestimated. MicroRNAs or miRNAs represent an important class of regulatory RNAs that primarily regulate gene expression levels post-transcriptionally. They are approximately 22 nucleotides in length and regulate the expression of approximately one-third of protein-coding genes in all mammals. At present, there are literatures showing that miRNA is very important to the occurrence, development, diagnosis, treatment a...

Claims

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Application Information

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IPC IPC(8): G16B25/00G16B40/00G16B50/30
CPCG16B25/00G16B40/00G16B50/30Y02A90/10
Inventor 李爱民刘雅君费蓉刘光明黑新宏王磊周红芳
Owner XIAN UNIV OF TECH
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