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A kind of red hair algae polysaccharide and its preparation method and application

A technology of red hair algae and polysaccharides, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, drug combinations, etc., and can solve problems such as affecting the therapeutic effect, patients' resistance to chemotherapy, and toxic and side effects of chemical drug treatment.

Active Publication Date: 2021-09-28
XIAMEN MEDICAL COLLEGE +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the pathogenesis of ovarian cancer has not been thoroughly studied in current clinical medical research. Some scholars have stated in their research that the onset of ovarian cancer symptoms may be related to genetic factors and endocrine factors.
The current standard treatment for ovarian cancer is surgical treatment, with cisplatin-based combined chemotherapy as an adjuvant after surgery, but chemotherapy may have obvious side effects, and some patients may develop chemotherapy resistance, which affects the therapeutic effect

Method used

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  • A kind of red hair algae polysaccharide and its preparation method and application
  • A kind of red hair algae polysaccharide and its preparation method and application
  • A kind of red hair algae polysaccharide and its preparation method and application

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Embodiment Construction

[0020] In order to make the content of the present invention easier to understand, the technical solutions of the present invention will be further described below in conjunction with specific embodiments, but the present invention is not limited thereto.

[0021] 1. Extraction and Isolation of Polysaccharides from Phalax algae

[0022] (1) Preparation of crude polysaccharides from red algae

[0023] Red hair algae were cleaned to remove impurities such as soil, then dried in a cold air dryer, cut into small pieces, added deionized water at a ratio of 1:40 g / mL to material and liquid, extracted in a water bath at 100°C for 4 hours, filtered, The filter residue was extracted with deionized water at a material-to-liquid ratio of 1:40 g / mL and repeated extraction once under the aforementioned conditions, then filtered, the two extracts were combined, and concentrated to 25% of the original volume; Double the volume of ethanol solution with a mass concentration of 85%, alcohol pr...

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Abstract

The invention discloses a red hair algae polysaccharide and its preparation method and application. The red hair algae polysaccharide is composed of rhamnose, arabinose, mannose, glucose and galactose, and it is effective against ovarian cancer cell lines A2780, COC1, SKOV3, HO‑8910 and OVCAR3 all have significant inhibitory effects and are expected to be used in the preparation of drugs for treating ovarian cancer.

Description

technical field [0001] The invention belongs to the technical field of extraction of natural components, and in particular relates to a red hair algae polysaccharide and its preparation method and application. Background technique [0002] Ovarian cancer is the deadliest gynecological malignancy worldwide, seriously affecting the quality of life and health of female patients. However, the pathogenesis of ovarian cancer has not been thoroughly studied in current clinical medical research. Some scholars have indicated in their research that the onset of ovarian cancer symptoms may be related to genetic factors and endocrine factors. The current standard treatment for ovarian cancer is surgical treatment with cisplatin-based combined chemotherapy as an adjuvant after surgery, but chemotherapy may have obvious side effects, and some patients may develop chemotherapy resistance, which affects the therapeutic effect. A large number of studies have shown that plant polysaccharides...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/00A61K31/715A61P35/00
CPCA61K31/715A61P35/00C08B37/0003C08B37/006
Inventor 吴靖娜刘智禹陈晓婷
Owner XIAMEN MEDICAL COLLEGE
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