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Preparation method and application of non-irritating Gynura divaricate active substance

A technology of cabbage and active substances, which can be used in skin care preparations, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve problems such as indeterminate biological activity, and achieve the effect of reducing irritation and improving moisturizing performance.

Active Publication Date: 2020-06-26
北京果素堂生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the inventor attempts to form an anti-aging facial mask (CN108703936A) with the ethanol extract of Chinese cabbage and the flavonoids of peony flower stamen, loquat leaf flavonoids, pearl powder, avocado oil and rice washing water. However, the anti-aging function is The synergistic effect of each component, and the biological activity represented by the alcohol extract of Chinese cabbage can not be determined. At present, there is no use of related extracts of Chinese cabbage for whitening

Method used

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  • Preparation method and application of non-irritating Gynura divaricate active substance
  • Preparation method and application of non-irritating Gynura divaricate active substance
  • Preparation method and application of non-irritating Gynura divaricate active substance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1, the preparation of the alcoholic extract of Chinese cabbage

[0025] Take the root of Baizicai as raw material, wash it, crush it into a powder with a particle size of 40 mesh, add 80% ethanol solution of 8 times the total amount of the powder, heat and reflux for extraction twice, each time for 1.5h, and the extraction temperature is 70°C , Filtrate, combine the filtrates, remove ethanol under reduced pressure, and concentrate.

[0026] According to the above method, 75% and 65% ethanol solutions are used for extraction to obtain 75% ethanol extract and 65% ethanol extract respectively.

Embodiment 2

[0027] Embodiment two, the preparation of water extract of Chinese cabbage

[0028] Take the root of Baizicai as raw material, wash it, crush it into a 40-mesh powder, add 8 times the total amount of the coarse powder, and extract it twice with hot water at a temperature of 80°C, 6 hours each time, filter, combine the filtrates, and concentrate, that is have to.

Embodiment 3

[0029] Example 3. Comparison of Whitening Activity and Stimulus of Alcoholic Extract and Water Extract of Brassica chinensis

[0030] 3.1 Comparison of whitening activity

[0031] Each group of samples was diluted with disodium hydrogen phosphate-citric acid buffer solution (pH6.8, 0.05mol / L) to obtain multi-level concentration samples, and samples of each concentration were taken in glass test tubes, and tyrosinase solution was added respectively; at 30°C After reacting in a water bath for 10 minutes, add levodopa solution to each group of glass test tubes in turn, then react in a water bath at 30°C for 10 minutes, and measure the OD value at 475 nm. The experimental system is shown in Table 1.

[0032]

[0033] In the formula: T is the absorbance value of the sample tube, that is, the absorbance value of the solution after the sample reacts with tyrosinase; T 0 is the background absorbance value of the sample; C is the average value of the three times of the absorbance v...

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Abstract

The invention relates to a preparation method and application of a non-irritating Gynura divaricate active substance. The preparation method of the active substance comprises the steps as follows: S1,preparation of a Gynura divaricate ethanol extract: roots or stems of Gynura divaricate as raw materials and are thoroughly cleaned and crushed, ethanol is removed by a heating reflux method with anethanol solution at a concentration of 65-85% as an extraction solvent in a solid-liquid ratio of 1: (5-10), and concentration is carried out to prepare the ethanol extract; S2, fermentation: a 30 L fermentation tank I inoculated with secondarily cultured xylaria nigripes in an inoculation quantity of 10%, the ethanol extract is added to the fermentation tank and fermented at 25 DEG C-30 DEG C for40-80 h to obtain a fermented filtrate; and S3, the fermented filtrate is taken and filtered with an ultrafiltration membrane to obtain a fermented active substance. The xylaria nigripes is adopted for biological fermentation of the Gynura divaricate ethanol extract, the irritation of the active substance to skin is significantly reduced, irritation intensity is reduced to no irradiation from medium irritation, the active substance is endowed with better moisturizing performance after fermentation by the xylaria nigripes, and the active substance can be applied to preparation of cosmetics asa skin whitening, moisturizing and non-irritating active component.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to a method for preparing a non-irritating active substance of Chinese cabbage and its application in preparing non-irritating cosmetics and / or skin care products with whitening and moisturizing effects. Background technique [0002] Gynura divaricata DC (Gynura divaricata DC) is a plant of the genus Sanqi in the family Compositae, also known as Panax notoginseng, Jiangtangcao, etc. It is widely used to treat hyperlipidemia and diabetes. For example, see Chinese invention patent applications CN102631391A, CN104644734A and CN110279873A. [0003] The most widely used is the aerial part of Chinese cabbage at present, and the extract of the aerial part of Chinese cabbage contains many components. Sterols, nucleosides, phenolic acids and esters, etc. Some scholars have analyzed the volatile oil content of different medicinal parts of Baizicai, and identified a variety of chemical com...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61Q19/00A61Q19/02
CPCA61K2800/72A61K2800/782A61K2800/85A61Q19/00A61Q19/02A61K8/9789
Inventor 陈广文
Owner 北京果素堂生物科技有限公司
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