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Small peptide tat-akpd for treating ischemic brain injury and its application

A technology of TAT-AKPD and ischemic brain injury, which is applied in the field of biomedicine, can solve the problems of ineffective treatment of neuron damage, and achieve the effects of convenient drug administration, reducing cell apoptosis, and ensuring effectiveness

Active Publication Date: 2021-07-27
XUZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] From the above discussion, it can be seen that many neuroprotective drugs in clinical practice cannot effectively treat neuronal damage caused by stroke.

Method used

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  • Small peptide tat-akpd for treating ischemic brain injury and its application
  • Small peptide tat-akpd for treating ischemic brain injury and its application
  • Small peptide tat-akpd for treating ischemic brain injury and its application

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Embodiment 1

[0020] Embodiment of the present invention is small peptides TAT-AKPD treatment of ischemic brain injury embodiment used, based Procaspase-7 binding and transfer between XIAP and nitrosylated designed, having the sequence: H-YGRKKRRQRRR-AKPD-OH , SEQ ID NO.1.

[0021]Endogenous Procaspase-7 occurred after cerebral ischemia, and hydrolyzed activation occurs, which in turn leads to apoptosis. The activity of caspases is regulated by apoptosis inhibitory protein family (IAPS), wherein X-link inhibitos Protein, XIAP is directly combined with Procaspase-7 through its BIR domain. And inhibit its activity. After the cerebral ischemia, XIAP has a nitrogenization, thereby inhibiting its anti-apoptotic activity.

[0022] According to the amino acid sequence of Procaspase-7 and XIAP binding sites, the four amino acids of the small peptide TAT-AKPD, and the procaspase-7 AKPD constitute a motif, responsible for binding to XIAP; TAT derived from a group of 11 amino acids on a slow virus The seq...

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Abstract

The invention discloses a small peptide TAT-AKPD for treating ischemic brain injury and its application. The full sequence of the small peptide TAT-AKPD is H-YGRKKRRQRRR-AKPD-OH. After using the small peptide TAT-AKPD of the present invention, the combination of XIAP and Procaspase-7 can be reduced, the transnitrosylation of Procaspase-7 and XIAP and the activation of Procaspase-7 can be reduced, and finally the apoptosis induced by cerebral ischemia can be alleviated. In addition, TAT can directly bring the fused small peptide into the cell, which solves the problem of the way for the drug to enter the cell and facilitates drug administration. Finally, the small peptide TAT‑AKPD has no immunogenicity, does not cause the body to produce an immune response, reduces side effects, and ensures the effectiveness of more than two administrations.

Description

Technical field [0001] The present invention belongs to the field of biotechnology medicine, it relates to small peptides TAT-AKPD and its application for treatment of ischemic brain injury. Background technique [0002] Stroke is one of the three causes of death worldwide. Wherein ischemic stroke is the main type of stroke, it has the characteristics of high morbidity and high mortality. With the increase of aging population and a variety of risk factors, ischemic stroke, the proportion is increasing. Ischemic stroke (stroke) including cerebral thrombosis, cerebral embolism, lacunar infarction and the like, accounting for about 70% of stroke. Stroke process a large number of neurons die, resulting in irreversible damage to neurons, but the legacy of post-stroke neurological sequelae will seriously affect the quality of life of patients. [0003] Existing drugs for treatment of ischemic brain damage mainly to improve cerebral circulation of drugs, neuroprotective drugs and tradit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K5/103A61K38/07A61K47/64A61P9/10
CPCA61K38/07A61K47/645A61P9/10C07K5/1008C07K2319/10
Inventor 胡书群姚君伟燕宪亮吕兰欣韩东颜晓庆杨红宁
Owner XUZHOU MEDICAL UNIV
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