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Application of ferroptosis inhibitor in preparation of medicine for treating acute liver injury

A technology for acute liver injury and ferroptosis, applied in drug combinations, pharmaceutical formulations, organic active ingredients, etc.

Inactive Publication Date: 2020-06-12
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far there is no report on the role of ferroptosis and its inhibitors in acute liver injury

Method used

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  • Application of ferroptosis inhibitor in preparation of medicine for treating acute liver injury
  • Application of ferroptosis inhibitor in preparation of medicine for treating acute liver injury
  • Application of ferroptosis inhibitor in preparation of medicine for treating acute liver injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Application of Fer-1 in acute liver injury induced by TAA.

[0040] (1) Experimental grouping:

[0041] Twenty-four male ICR inbred mice (6-8 weeks, 18-22g) were randomly divided into 3 groups according to body weight, namely normal control group, TAA model group, and TAA+Fer-1 group, with 8 mice in each group.

[0042] (2) Experimental treatment:

[0043] Three days before intraperitoneal injection of TAA injection (250mg / kg / day, volume 0.25ml, for 3 consecutive days) to the mice in each group (except the normal control group mice), the mice in the TAA model group were given intraperitoneal injection of 0.25 ml of normal saline, and given Fer-1 injection (1 mg / kg / day, volume 0.25ml for 3 consecutive days) to mice in TAA+Fer-1 group.

[0044] The mice in the normal control group were given intraperitoneal injection of 0.25 ml of normal saline twice. In order to exclude the influence of time, the time of the two injections of normal saline was the same as that of the o...

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Abstract

The invention discloses an application of a ferroptosis inhibitor in preparation of a medicine for treating an acute liver injury. A ferroptosis inhibitor is pretreated to remarkably reduce levels ofglutamic-pyruvic transaminase ALT and glutamic oxalacetic transaminase AST in serum after the acute liver injury induced by sodium thiosulfate TAA; an MDA content in liver tissues after the TAA-induced acute liver injury is reduced, and the contents of reduced glutathione GSH and glutathione peroxidase GSH-PX in the liver tissues are increased; infiltration of inflammatory cells in the TAA-inducedacute liver injury to a liver is reduced; and a protective effect of the ferroptosis inhibitor on the TAA-induced acute liver injury is related to inhibition of hepatocyte ferroptosis, and ferroptosis marker gene glutamic acid / cystine reverse transporter xCT and Gpx4 glutathione peroxidase 4 in a TAA-induced acute liver injury model can be remarkably improved by the ferroptosis inhibitor.

Description

technical field [0001] The invention relates to the technical field of biopharmaceuticals, in particular to the application of ferroptosis inhibitors in the preparation of medicines for treating acute liver injury. Background technique [0002] Liver disease is a huge global public health problem that threatens the health of billions of people. What's more, the incidence of many liver diseases is gradually increasing. Increased immigration, frequent travel and economic globalization have all contributed to the widespread spread of the virus. Acute liver injury refers to acute and severe liver insufficiency in people without liver disease due to massive death or loss of liver cells. The structure and function of the liver are relatively complex. As an important organ for protein synthesis and storage, it provides various substances for the body to operate and regulate the stability of other tissues and organs. Not only that, the liver is also the main storage place of iron...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/245A61P1/16
CPCA61K31/245A61P1/16
Inventor 骆倩倩胡佳楠李美琦王国华陆亚鹏朱俐
Owner NANTONG UNIVERSITY
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