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Double-negative acoustic metamaterial for transcranial ultrasonic imaging based on Mie resonance

An acoustic metamaterial and ultrasonic imaging technology, which is applied in the field of acoustic metamaterials to achieve great application value and eliminate dissipation and distortion effects.

Active Publication Date: 2020-06-09
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In short, the skull has a strong attenuation and distortion effect on ultrasound, and it is difficult for ultrasound to effectively penetrate the skull to achieve intracranial tissue and blood flow imaging in conventional ways

Method used

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  • Double-negative acoustic metamaterial for transcranial ultrasonic imaging based on Mie resonance
  • Double-negative acoustic metamaterial for transcranial ultrasonic imaging based on Mie resonance
  • Double-negative acoustic metamaterial for transcranial ultrasonic imaging based on Mie resonance

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Embodiment 1

[0032] The density of porous hydrogel microspheres is 500kg / m 3 , the sound velocity is 120m / s, the radius is 50μm; the density of the ultrasonic coupling agent is 900kg / m 3 , the sound velocity is 1400m / s; the porous hydrogel microspheres are uniformly dispersed in the ultrasonic coupling agent matrix to obtain the desired double negative acoustic metamaterial, wherein the volume fraction of the porous hydrogel microspheres is 15%. The curves of equivalent mass density and equivalent elastic modulus with frequency calculated based on the multiple scattering model are as follows: image 3 As shown, the acoustic metamaterial simultaneously exhibits a negative equivalent mass density and a negative equivalent elastic modulus at a frequency of 0.63-0.67 MHz.

Embodiment 2

[0034] The density of porous hydrogel microspheres is 600kg / m 3 , the sound velocity is 150m / s, the radius is 60μm; the density of the ultrasonic coupling agent is 1000kg / m 3 , the sound velocity is 1500m / s; the porous hydrogel microspheres are uniformly dispersed in the ultrasonic coupling agent matrix to obtain the required double negative acoustic metamaterial, wherein the volume fraction of the porous hydrogel microspheres is 20%. The curves of equivalent mass density and equivalent elastic modulus with frequency calculated based on the multiple scattering model are as follows: Figure 4 As shown, the acoustic metamaterial exhibits negative equivalent mass density and negative equivalent elastic modulus at the frequency of 0.67-0.70 MHz.

Embodiment 3

[0036] The density of porous hydrogel microspheres is 700kg / m 3 , the sound velocity is 180m / s, the radius is 70μm; the density of the ultrasonic coupling agent is 1100kg / m 3 , the sound velocity is 1600m / s; the porous hydrogel microspheres are uniformly dispersed in the ultrasonic coupling agent matrix to obtain the desired double negative acoustic metamaterial, wherein the volume fraction of the porous hydrogel microspheres is 25%. The curves of equivalent mass density and equivalent elastic modulus with frequency calculated based on the multiple scattering model are as follows: Figure 5 As shown, the acoustic metamaterial exhibits negative equivalent mass density and negative equivalent elastic modulus at the frequency of 0.68-0.73 MHz.

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Abstract

The invention discloses a double-negative acoustic metamaterial based on Mie resonance and used for transcranial ultrasonic imaging. The double-negative acoustic metamaterial comprises an ultrasonic coupling agent as a matrix and a scatterer dispersed in the matrix and used for generating Mie resonance, wherein the scatterer is porous polyethylene glycol diacrylate hydrogel microspheres; and the volume fraction of the porous polyethylene glycol diacrylate hydrogel microspheres in the matrix is 15-25%. The double-negative type acoustic metamaterial provided by the invention can effectively eliminate the dissipation and distortion effects of the skull on sound waves, so that the double-negative type acoustic metamaterial is expected to realize transcranial ultrasonic imaging without depending on the natural existence of the skull or an artificially manufactured acoustic window.

Description

technical field [0001] The invention belongs to the field of acoustic metamaterials, in particular to a double-negative acoustic metamaterial based on Mie resonance for transcranial ultrasound imaging. Background technique [0002] In the medical field, magnetic resonance imaging (MRI), computed tomography (CT) and brain ultrasound are the main imaging diagnostic methods for brain diseases. Although MRI is generally considered the most suitable method for brain examination, and CT also has its excellent diagnostic value, in some cases, brain ultrasound has an irreplaceable role. First, cranial ultrasound can provide hemodynamic information that cannot be obtained by MRI and CT; second, cranial ultrasound equipment is light and suitable for bedside detection and long-term dynamic monitoring in emergency departments such as ambulances, emergency rooms, and intensive care units. Especially for critically ill patients who cannot be moved, bedside examination can be implemented;...

Claims

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Application Information

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IPC IPC(8): G10K11/162G10K11/172C08L83/04C08L55/00C08J9/08
CPCG10K11/172G10K11/162C08J9/08C08J2383/04C08J2455/00C08J2203/02
Inventor 黄玉辉吴勇军金一铭陈洁
Owner ZHEJIANG UNIV
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