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Application of novel loquat leaf sesquiterpene glycoside in relieving liver cell lipid deposition

A technology of sesquiterpene glycosides and lipid deposition, applied in the field of medicine, can solve the problem of incomplete research on liver protection, achieve the effect of reducing lipid deposition in liver cells and expanding types

Active Publication Date: 2020-06-05
INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, its liver protection effect has not been fully studied.

Method used

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  • Application of novel loquat leaf sesquiterpene glycoside in relieving liver cell lipid deposition
  • Application of novel loquat leaf sesquiterpene glycoside in relieving liver cell lipid deposition
  • Application of novel loquat leaf sesquiterpene glycoside in relieving liver cell lipid deposition

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Experimental program
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Effect test

Embodiment 1

[0025] The preparation embodiment of loquat leaf sesquiterpene glycoside D

[0026] Take 1kg of dried loquat leaves, crush them, soak and extract 3 times with 10L ethanol solution with a concentration of 80% by mass at room temperature, combine the extracts, filter, concentrate under reduced pressure until there is precipitation, centrifuge at 3000 rpm for 15 minutes, and take the supernatant Liquid standby;

[0027] The above supernatant was slowly flowed through the XAD16 macroporous adsorption resin column, and eluted with a water-ethanol gradient. After detection and analysis by high performance liquid phase, the fractions with an ethanol concentration between 60-80% were combined, concentrated under reduced pressure, and set aside.

[0028] The above-mentioned concentrated solution further flows through a treated polyamide (200 mesh, 200g) column, and is eluted with a water-methanol gradient. Concentrated, the concentrated solution is further subjected to reverse ODS col...

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Abstract

The invention discloses application of novel loquat leaf sesquiterpene glycoside in relieving liver cell lipid deposition, and also discloses application in preparation of drugs and health-care foodsfor preventing or treating non-alcoholic fatty liver. The name of the sesquiterpene glycoside is nerolidol-3-O-alpha-L-arabinopyranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1-> 2)-[alpha-L-rhamnopyranosyl-(1-> 6)]-beta-D-glucopyranoside.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a novel sesquiterpene glycoside compound extracted from nature, which can prevent and treat non-alcoholic fatty liver by reducing lipid deposition in liver cells. Background technique [0002] With the development of the economy, people's dietary structure and lifestyle changes, irrational nutritional intake, excess energy and other phenomena appear, resulting in a significant increase in the incidence of nonalcoholic fatty liver disease (NAFLD). Non-alcoholic fatty liver refers to a clinicopathological syndrome characterized by excessive fat deposition in liver cells caused by excluding alcohol factors. It is the main pathological manifestation of metabolic syndrome in the liver, including simple fatty liver and more dangerous non-alcoholic fatty liver disease. Alcoholic steatohepatitis (NASH), nonalcoholic steatohepatitis can further develop into liver cirrhosis and liver failure, which...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7028A61P1/16A61P3/04C07H15/10A23L33/105
CPCA23V2002/00A61K31/7028A23L33/105A61P1/16A61P3/04C07H15/10A23V2200/3324A23V2250/21
Inventor 丁晓琴陈剑李佳伟简暾昱吕寒任冰如童贝马丽孟秀花
Owner INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI
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