Hydroxyapatite forming method, hydroxyapatite and application of hydroxyapatite

A technology of hydroxyapatite and molding methods, applied in chemical instruments and methods, phosphorus compounds, inorganic chemistry, etc., can solve the problems of easy swelling, low mechanical strength, and cannot be used dry, and achieve high sphericity and high adsorption performance , the effect of uniform particle size

Active Publication Date: 2020-06-02
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The small spheres formed by pure alginate are brittle, have low mechanical strength, and are easy to swell, so they cannot be used dry

Method used

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  • Hydroxyapatite forming method, hydroxyapatite and application of hydroxyapatite
  • Hydroxyapatite forming method, hydroxyapatite and application of hydroxyapatite
  • Hydroxyapatite forming method, hydroxyapatite and application of hydroxyapatite

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Take 74.8 g of anhydrous calcium chloride and 52.8 g of ammonium dihydrogen phosphate and dissolve them in 1600 mL of water respectively, mix the calcium chloride solution and ammonium dihydrogen phosphate solution under mechanical stirring, and adjust the pH value of the solution to 10.4 with ammonia water. Continue to stir for 15 minutes, put it into a 90°C water bath, continue to stir and heat for 2 hours, cool at room temperature and let it stand for aging for 12 hours, and filter the obtained precipitate with a Buchner funnel under reduced pressure. 6.69 g of the precipitate was dissolved in 15.61 g of deionized water to obtain 22.3 g of a 30% hydroxyapatite dispersion. Add the dispersion liquid to 20 g of 3% sodium alginate solution, and disperse with magnetic stirring for 30 min to obtain a suspension of hydroxyapatite. Take the above suspension and drop it into 300mL 0.2M calcium nitrate aqueous solution, after aging in the calcium nitrate solution for 2 hours, ...

Embodiment 2

[0030] The preparation steps of hydroxyapatite are the same as in Example 1, except that 8 g of hydroxyapatite precipitate is added to 40 g of 1% sodium alginate solution, stirred and dispersed for 30 minutes to obtain a suspension of hydroxyapatite. Take the suspension above and drop it into 300mL of 0.5M calcium nitrate solution. After aging in the calcium nitrate solution for 10 hours, take it out and dry it at 60°C for 24h at room temperature, and then roast it at 500°C for 3h to obtain spherical hydroxyapatite with a diameter of 2.5mm. real photo see figure 2 . It can be seen from the figure that the outer surface of the pellets is smooth, spherical, and the particle size is uniform. The mechanical strength is measured by a DL III-500 strength tester, and the average mechanical strength can reach 148N / piece.

Embodiment 3

[0032] The preparation steps of hydroxyapatite are the same as those in Example 1, except that 6 g of hydroxyapatite precipitate is added to 30 g of 2% sodium alginate solution, stirred and dispersed for 180 min to obtain a suspension of hydroxyapatite. Take the above suspension and drop it into 300mL 2M calcium nitrate solution, age in the calcium nitrate solution for 1 hour, take it out and dry it at room temperature at 120°C for 8 hours, then roast it at 700°C for 1 hour to obtain spherical hydroxyapatite with a diameter of 2-5mm , real photos such as image 3 . It can be seen from the figure that the outer surface of the small ball is smooth, the small particle is in the shape of a sphere, and the large particle is in the shape of an ellipse. The mechanical strength is measured by a DL III-500 strength tester, and the average mechanical strength can reach 162N / piece.

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Abstract

The invention discloses a forming method of spherical hydroxyapatite, hydroxyapatite and application of the hydroxyapatite. The forming method specifically comprises the following steps: uniformly stirring and mixing a calcium chloride aqueous solution and an ammonium dihydrogen phosphate aqueous solution, filtering to obtain a hydroxyapatite precipitate, and directly dispersing the hydroxyapatiteprecipitate into deionized water without washing to obtain a turbid liquid; and mixing the hydroxyapatite turbid liquid and an alginate aqueous solution to form slurry, then adding the slurry into ametal salt solution in a dropwise manner, solidifying the hydroxyapatite into gel balls, and drying and roasting to obtain the spherical hydroxyapatite. The preparation method is simple in process, and the prepared spherical hydroxyapatite is high in sphericity degree and strength and has wide application prospects in the fields of catalysis, adsorption separation and bioengineering.

Description

technical field [0001] The invention belongs to the field of porous material preparation, and in particular relates to a molding method of spherical hydroxyapatite, hydroxyapatite and its application. Background technique [0002] Hydroxyapatite (HAP), the main inorganic component of animal bones, has excellent biocompatibility and bioactivity. At the same time, hydroxyapatite has unique ion exchange properties, and the anion and cation positions in its structure can be replaced by other ions. At the same time, Ca can also be generated during the formation of hydroxyapatite 2+ In the deficient form, non-stoichiometric hydroxyapatite (Ca / P=1.4-1.67) is formed, thereby adjusting the surface acidity and alkalinity of hydroxyapatite. The structure of hydroxyapatite is stable, and the perfect HAP structure can still be maintained when calcined at 1200 °C. In addition, hydroxyapatite also has a strong adsorption capacity. It is because of these characteristics that hydroxyapati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/447C04B35/624C01B25/32
CPCC01B25/325C01P2004/01C04B35/447C04B35/624C04B2235/96
Inventor 樊斯斯徐金铭黄延强黄庆连洪万墩陈博明吴建慧郑雅文温明宪张朝钦黄朝晟
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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