Metabolite composition for pre-operative early warning of transplanted kidney delayed rework of donation receptor after cardiac death and screening method thereof

A technique for cardiac death and screening methods, applied in the field of analysis, can solve problems such as differential analysis that has not yet been reported, and achieve the effect of reducing the probability of occurrence and delaying the recovery of power.

Active Publication Date: 2020-05-29
ZHEJIANG UNIV
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Problems solved by technology

At present, the analysis of delayed recovery events in renal transplantation based on metabolomics technology comes from the postoperative samples of the recipients, and the difference analysis of the preoperative recipients has not been reported yet.

Method used

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  • Metabolite composition for pre-operative early warning of transplanted kidney delayed rework of donation receptor after cardiac death and screening method thereof
  • Metabolite composition for pre-operative early warning of transplanted kidney delayed rework of donation receptor after cardiac death and screening method thereof
  • Metabolite composition for pre-operative early warning of transplanted kidney delayed rework of donation receptor after cardiac death and screening method thereof

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Embodiment 1

[0035] DGF after renal transplantation is a common clinical adverse event, and the diagnostic criteria are low urine output within 1 week after operation and the need for transition to dialysis. Two kidneys from the same donor will have differences in functional recovery in different recipients. According to the postoperative renal function recovery of the recipients, the DCD kidney transplant recipients are grouped: the recipients with postoperative DGF are Receptor -DGF (DGF) group, the recipient with stable renal function recovery is the Receptor-Stable (Stable) group, and preoperative blood samples were obtained from the above two groups.

[0036]Stable recovery of renal function was defined as postoperative serum creatinine was stable within 20% of the baseline value, and there were no postoperative complications such as acute rejection, lymphatic leakage, urinary fistula, perirenal hematoma, and polyoma virus infection. The diagnosis of acute rejection was made by the tr...

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Abstract

The invention discloses a metabolic composition for pre-operative early warning of transplanted kidney delayed rework of a donation receptor after cardiac death. The metabolic composition is composedof one or more than one of four metabolites including glucuronic acid, ganglioside, physalis angulata sterol and thiophenol. The invention further discloses a screening method of the pre-operative early warning of transplanted kidney delayed rework of donation receptor after cardiac death. In the screened metabolic composition, the combination indication rate of glucuronic acid and ganglioside is0.885, and the combination indication rate of physalis angulata sterol and thiophenol is 0.953.

Description

technical field [0001] The invention belongs to the field of analysis technology, and specifically relates to a metabolic composition and a screening method for pre-warning and delaying recovery of transplanted kidneys donated after cardiac death. Background technique [0002] Delayed graft function (DGF) is a clinical phenomenon that fails to recover physiological function within one week after kidney transplantation and requires transition to dialysis, and is an independent risk factor affecting the survival of transplanted kidney [P.N.C.D.S.M. et al., Delayed graft function in kidney transplantation. Lancet, 2004. 364(9447)]. In recent years, with the popularization of donation after cardiac death (DCD), the incidence of DGF has increased significantly. On the one hand, the acquisition of DCD kidneys can only be carried out after the donor’s heart function stops, so the donor kidney will experience a longer warm ischemia time than the living donor kidney, and the changes...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/34G01N30/36G01N30/72G01N30/88G16C20/64G16C20/70
CPCG01N30/02G01N30/06G01N30/34G01N30/36G01N30/7266G01N30/88G16C20/64G16C20/70G01N2030/027G01N2030/8822
Inventor 沈佳邓皓黄洪锋陈江华王仁定
Owner ZHEJIANG UNIV
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