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Curved surface shaped medical device having antibacterial coating and preparation method thereof

A curved surface modeling and medical device technology, applied in the direction of coatings, catheters, etc., can solve the problems of film-forming aid residues, safety risks, etc., and achieve the effect of ensuring sterilization performance, good adaptability, and reducing the risk of bacterial infection

Active Publication Date: 2020-05-22
JIANGSU BIOSURF BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the process of making antibacterial coatings, it is usually necessary to add film-forming additives to improve the film-forming quality and performance of nanoparticles on curved surfaces. The possibility of release, causing safety risks

Method used

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  • Curved surface shaped medical device having antibacterial coating and preparation method thereof
  • Curved surface shaped medical device having antibacterial coating and preparation method thereof

Examples

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Embodiment 1

[0031] This embodiment relates to a method for preparing a curved medical device with an antibacterial coating, comprising the following steps:

[0032] S1, 8mmol of N-vinylcaprolactam, 1.2mmol of vinylimidazole and 1.2mmol of 1,6-dibromohexane were added to a three-necked flask containing 198mL of deionized water, stirred slowly, and introduced inert gas nitrogen and Under the condition of condensing and reflux, raise the temperature to 70°C and keep it warm for 10 minutes; then add 2 mL of deionized water containing 100 mg of azobisisobutylamidine hydrochloride to initiate the reaction; continue to blow nitrogen, stir at a medium speed of 350-500 rpm, and condense and reflux Under the conditions, the reaction was continued for 8 hours; finally, the temperature was slowly cooled to room temperature to obtain quaternary ammonium salt type poly(N-vinylcaprolactam) microgel particles with a particle size between 300-400nm;

[0033] S2, dispersing the quaternary ammonium salt typ...

Embodiment 2

[0039] This embodiment relates to a method for preparing a curved medical device with an antibacterial coating, comprising the following steps:

[0040] S1, 8mmol of N-vinylcaprolactam, 2.4mmol of vinylimidazole and 1.2mmol of 1,8-dibromooctane were added to a three-necked flask containing 198mL of deionized water, under the conditions of slow stirring, nitrogen flow and condensing and reflux , heat up to 70°C, and keep warm for 10 minutes; then add 2 mL of deionized water containing 150 mg of azobisisobutylamidine hydrochloride to initiate the reaction; under the conditions of continuous nitrogen flow, 350-500 rpm medium-speed stirring and condensing and reflux, Continue to react for 8 hours; finally, the temperature is slowly cooled to room temperature to obtain quaternary ammonium salt type poly(N-vinyl caprolactam) microgel particles with a particle diameter between 400-500nm;

[0041] S2, dispersing the quaternary ammonium salt type poly(N-vinyl caprolactam) microgel part...

Embodiment 3

[0044] This embodiment relates to a method for preparing a curved medical device with an antibacterial coating, comprising the following steps:

[0045] S1. Add 8mmol of N-isopropylacrylamide, 1.2mmol of vinylimidazole and 0.6mmol of 1,5-dibromobutane into a three-necked flask containing 198mL of deionized water, stir slowly, blow nitrogen and condense Under reflux conditions, raise the temperature to 70°C and keep it warm for 10 minutes; then add 2 mL of deionized water containing 150 mg of azobisisobutylamidine hydrochloride to initiate the reaction; The reaction was continued for 8 hours; finally, the temperature was slowly cooled to room temperature to obtain quaternary ammonium salt type poly(N-isopropylacrylamide) microgel particles with a particle diameter between 350-500nm;

[0046] S2, dispersing the quaternary ammonium salt type poly(N-vinyl caprolactam) microgel particles prepared in S1 in ethanol to make a dispersion;

[0047] S3, using the dip coating method to c...

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Abstract

The invention provides a curved surface shaped medical device having an antibacterial coating and a preparation method thereof, and belongs to the technical field of antibacterial materials. The preparation method of the curved surface shaped medical device having the antibacterial coating includes the following steps: preparing quaternary ammonium salt type microgel particles, and preparing a microgel dispersion liquid from the quaternary ammonium salt type microgel particles; coating the surface of the cleaned curved surface shaped medical device with the microgel dispersion liquid, after afirst solvent volatilizes completely, putting the curved surface shape medical device into deionized water for full soaking; after the device is fully soaked, putting the curved surface shape medicaldevice into a second solvent, and performing ultrasonic treatment; and after the ultrasonic treatment is completed, putting the device into deionized water for secondary soaking, and finally taking out the device, performing drying to obtain the curved surface shaped medical device having the antibacterial coating. The method uses the quaternary ammonium salt type microgel, and the antibacterial coating can be directly formed on the medical device having a certain-curvature surface.

Description

technical field [0001] The invention relates to a technology in the field of antibacterial materials, in particular to a curved surface-shaped medical device with an antibacterial coating and a preparation method thereof. Background technique [0002] Grafting polymers on the surface of materials to prevent bacteria from adhering, or modifying materials with bactericides that can directly kill bacteria are common strategies to improve the antibacterial properties of materials. The Chinese patent documents No. CN107115559A and CN107583112A respectively prepare a layer of silver nanoparticles on the surface of medical materials for antibacterial, and achieved good results. However, the application of Chinese Patent Document No. CN108866489A obtains broad-spectrum antibacterial properties by depositing a layer of titanium-copper-cerium nano-coating on the surface of medical titanium alloy materials. However, the preparation process of the above method is complicated, and the a...

Claims

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Application Information

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IPC IPC(8): A61L29/06A61L29/08A61L29/16A61L29/14
CPCA61L2300/404A61L2300/606A61L31/10A61L31/14A61L31/16C08F226/06C08F220/54A61L2420/02C08L39/04
Inventor 陈红陈蕊赵子青
Owner JIANGSU BIOSURF BIOTECH CO LTD
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