Method for preparing hydroxyapatite/L-polylactide composite bone scaffold
A technology of L-polylactic acid and hydroxyapatite, which is used in medical science, tissue regeneration, prosthesis, etc., can solve problems such as unsatisfactory strength, incompatibility between inorganic particles and polymer interfaces, and achieve excellent interface bonding ability, improve Mechanical properties, the effect of improving strength
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Embodiment 1
[0047] (1) Weigh 400 mg of dopamine and dissolve it in 200 mL of Tris-HCl buffer solution (pH=8.5) to prepare a polydopamine solution, then weigh 0.2 mg of PLLA powder with a particle size of 50 μm and a melting point of 180° C. into the polydopamine solution , the polydopamine-modified PLLA suspension was uniformly prepared by magnetic stirring and ultrasonic dispersion mixing, wherein the magnetic stirring time was 30 min, the magnetic stirring speed was 500 r / min, the stirring temperature was 50 ° C, the ultrasonic dispersion time was 40 min, and the ultrasonic dispersion temperature was 50°C;
[0048] (2) The polydopamine-modified PLLA suspension is centrifuged, washed with distilled water, dried, and ground to prepare polydopamine-modified PLLA powder; wherein the centrifugal separation speed is 2000r / min, the time is 25min, the drying temperature is 50°C, and the holding time 18h;
[0049] (3) Put the polydopamine-modified PLLA powder into 1.5 times the simulated body f...
Embodiment 2
[0065] Compared with Example 1, the main difference is that the in situ generation time of HAP is 1 day, and the specific operation is as follows:
[0066] (1) Weigh 400 mg of dopamine and dissolve it in 200 mL of Tris-HCl buffer solution (pH=8.5) to prepare a polydopamine solution, then weigh 0.2 mg of PLLA powder with a particle size of 50 μm and a melting point of 180° C. into the polydopamine solution , the polydopamine-modified PLLA suspension was uniformly prepared by magnetic stirring and ultrasonic dispersion mixing, wherein the magnetic stirring time was 30 min, the magnetic stirring speed was 500 r / min, the stirring temperature was 50 ° C, the ultrasonic dispersion time was 40 min, and the ultrasonic dispersion temperature was 50°C;
[0067] (2) The polydopamine-modified PLLA suspension is centrifuged, washed with distilled water, dried, and ground to prepare polydopamine-modified PLLA powder; wherein the centrifugal separation speed is 2000r / min, the time is 25min, ...
Embodiment 3
[0072] Compared with Example 1, the main difference is that the in-situ generation time of HAP is 5 days, and the specific operation is as follows:
[0073] (1) Weigh 400 mg of dopamine and dissolve it in 200 mL of Tris-HCl buffer solution (pH=8.5) to prepare a polydopamine solution, then weigh 0.2 mg of PLLA powder with a particle size of 50 μm and a melting point of 180° C. into the polydopamine solution , the polydopamine-modified PLLA suspension was uniformly prepared by magnetic stirring and ultrasonic dispersion mixing, wherein the magnetic stirring time was 30 min, the magnetic stirring speed was 500 r / min, the stirring temperature was 50 ° C, the ultrasonic dispersion time was 40 min, and the ultrasonic dispersion temperature was 50°C;
[0074] (2) The polydopamine-modified PLLA suspension is centrifuged, washed with distilled water, dried, and ground to prepare polydopamine-modified PLLA powder; wherein the centrifugal separation speed is 2000r / min, the time is 25min,...
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