Preparation method and applications of fiber-phase red phosphorus nanoparticles

A nanoparticle and fiber phase technology, applied in nanotechnology, nanotechnology, chemical instruments and methods, etc., can solve the problems of low antibiotic efficiency, damage to healthy tissues, etc. repeatable effect

Pending Publication Date: 2020-05-19
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antibiotics such as daptomycin and vancomycin are now used in combination with the photothermal effect of near-infrared (NIR) light to treat MRSA infections, but these antibiotics are not very effective
Furthermore, to achieve the lethal photothermal effect, the temperature used is still higher than 50 degrees Celsius, which may have damaged healthy tissue

Method used

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  • Preparation method and applications of fiber-phase red phosphorus nanoparticles
  • Preparation method and applications of fiber-phase red phosphorus nanoparticles
  • Preparation method and applications of fiber-phase red phosphorus nanoparticles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A fiber-phase red phosphorus nanoparticle, specifically prepared through the following steps:

[0035] (1) Synthesis of zinc oxide nanoparticles: 1.885 g of zinc nitrate hexahydrate, 2.185 g of sodium dodecylbenzenesulfonate and 6 g of sodium hydroxide were weighed and dissolved in 60 mL of ethanol with a balance. The solution is sonicated until the solute is uniformly dispersed in the solution. Put the sonicated solution into a 100mL reactor, put the reactor in a muffle furnace at 100°C, and react at high temperature for 9h. The reacted solution was centrifuged (9000r / min, 10min) to collect zinc oxide nanoparticles. Then centrifuged 3 times with absolute ethanol, and then centrifuged 3 times with deionized water. The precipitate after centrifugation was vacuum-dried in a vacuum oven at 60°C.

[0036] (2) Preparation of amorphous pure red phosphorus: Weigh 5.9 g of commercial amorphous red phosphorus and add it to 60 mL of deionized water, transfer the solution to a ...

Embodiment 2

[0050] A fiber-phase red phosphorus nanoparticle, specifically prepared through the following steps:

[0051] (1) Synthesis of zinc oxide nanoparticles: 1.885 g of zinc nitrate hexahydrate, 2.185 g of sodium dodecylbenzenesulfonate and 4.8 g of sodium hydroxide were weighed and dissolved in 60 mL of ethanol with a balance. The solution is sonicated until the solute is uniformly dispersed in the solution. Put the sonicated solution into a 100 mL reaction kettle, put the reaction kettle in a muffle furnace at 90°C, and react at high temperature for 11 hours. The reacted solution was centrifuged (9000r / min, 10 min) to collect zinc oxide nanoparticles. Then centrifuged 3 times with absolute ethanol, and then centrifuged 3 times with deionized water. The precipitate after centrifugation was vacuum-dried in a vacuum oven at 50°C.

[0052] Steps (2) (3) (4) are consistent with embodiment 1.

[0053] Scanning electron microscopy was carried out to the fiber-phase red phosphorus na...

Embodiment 3

[0055] A fiber-phase red phosphorus nanoparticle, specifically prepared through the following steps:

[0056] (1) Synthesis of zinc oxide nanoparticles: 1.885 g of zinc nitrate hexahydrate, 2.185 g of sodium dodecylbenzenesulfonate and 6 g of sodium hydroxide were weighed and dissolved in 60 mL of ethanol with a balance. The solution is sonicated until the solute is uniformly dispersed in the solution. Put the sonicated solution into a 100mL reaction kettle, put the reaction kettle in a muffle furnace at 105°C, and react at high temperature for 10h. The reacted solution was centrifuged (9000r / min, 10min) to collect zinc oxide nanoparticles. Then centrifuged three times with absolute ethanol, and then centrifuged three times with deionized water, and the precipitate after centrifugation was vacuum-dried at 65°C.

[0057] Step (2) (3) (4) is the same as embodiment 1;

[0058] The compound of zinc oxide nanoparticles and red phosphorus prepared above was detected by scanning e...

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Abstract

The invention relates to the field of novel functional nano materials, and discloses a preparation method and applications of fiber-phase red phosphorus nanoparticles. The method comprises the following steps: synthesizing zinc oxide nanoparticles through a hydrothermal method, depositing a layer of fiber-phase red phosphorus on the zinc oxide nanoparticles as a template through a chemical vapor deposition method, washing out the zinc oxide nanoparticles in the zinc oxide nanoparticle compound wrapped with the red phosphorus with diluted hydrochloric acid, and ultrasonically washing to obtainthe fiber-phase red phosphorus nanoparticles. The fiber-phase red phosphorus nanoparticles prepared by the method have good photo-thermal properties, can coordinate antibiotics to efficiently and quickly treat bacterial biofilm infection, and have good biocompatibility and good biodegradability.

Description

technical field [0001] The invention relates to the technical field of novel functional nanomaterials, in particular to a preparation method and application of fiber-phase red phosphorus nanoparticles with good photothermal properties. Background technique [0002] The escalating escalation of antibiotic-resistant bacterial infections poses a huge economic burden and seriously threatens human health care worldwide. According to the World Health Organization, more than 2 million people are infected with antibiotic-resistant pathogens and 2,300 people die each year. As one of the three major threats to human health, antibiotic-resistant pathogens are expected to surpass the threat of cancer in the near future in terms of morbidity and mortality. As conventional antibiotics are becoming increasingly ineffective and facing phase-out, the discovery of new effective antibiotics is urgently needed. Many new synthetic antimicrobials exhibit potent antimicrobial properties against ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/023B82Y30/00A61K31/7036A61K41/00A61K45/06A61P31/04
CPCC01B25/023B82Y30/00A61K41/0052A61K45/06A61K31/7036A61P31/04C01P2004/04C01P2002/82C01P2002/84C01P2004/62A61K2300/00
Inventor 刘想梅周子傲吴水林
Owner HUBEI UNIV
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