Composition for promoting production of hyaluronic acid

A technology of hyaluronic acid and composition, applied in the field of compositions for promoting the production of hyaluronic acid, can solve the problems of ignorance, never hinted, etc.

Pending Publication Date: 2020-05-15
เฮ้าส์ เวลล์เนสส์ ฟูดส์ คอร์ปอเรชั่น
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] For Lactobacillus plantarum L-137, it is known that it has various effects such as preventing colds (Patent Documents 1-6 and Non-Patent Documents 1-10), but for the effect of Lactobacillus plantarum L-137 on promoting the proliferation of fibroblasts and The role of promoting hyaluronan synthase gene expression is unknown or even suggested

Method used

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  • Composition for promoting production of hyaluronic acid
  • Composition for promoting production of hyaluronic acid
  • Composition for promoting production of hyaluronic acid

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preparation example Construction

[0096] The present invention provides a method for preparing a composition containing hyaluronic acid, which has the method of contacting (1) (a) Lactobacillus plantarum L-137 and (b) immune cells or immune cell production components with (2) fibroblasts process.

[0097] Fibroblasts may be fibroblasts present in mammals including humans, or fibroblasts present in vitro, but are preferably fibroblasts present in vivo. The contact of the above-mentioned components (1) and (2) can be produced by oral intake of the component (1) or application on the skin, or by adding the component (1) to the culture medium of the component (2) .

[0098] The present invention provides a hyaluronic acid-containing composition (hereinafter also referred to as the hyaluronic acid-containing composition of the present invention) produced by the above-mentioned production method.

[0099] The hyaluronic acid-containing composition of the present invention may contain the above-mentioned component ...

Embodiment 1

[0107] 2.5× 10 6 BALB / c mouse splenocytes as immune cells were cultured at 37° C. for 48 hours, and the culture medium was recovered to obtain splenocyte culture supernatant. Mouse fibroblasts (BALB / 3T3 clone A31) were incubated at 37°C for 3 hours.

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Abstract

The purpose of the present invention is to provide a composition for promoting the proliferation of a fibroblast and / or a composition for promoting the expression of a hyaluronic acid synthase gene. The present invention provides a composition containing Lactobacillus plantarum L-137 and used for promoting the proliferation of the fibroblast and / or the composition for promoting the expression of the hyaluronic acid synthase gene.

Description

technical field [0001] The present invention relates to a composition for promoting the production of hyaluronic acid, and more specifically, relates to a composition for promoting the production of hyaluronic acid containing Lactobacillus plantarum L-137. Background technique [0002] For Lactobacillus plantarum L-137, it is known that it has various effects such as preventing colds (Patent Documents 1-6 and Non-Patent Documents 1-10), but for the effect of Lactobacillus plantarum L-137 on promoting the proliferation of fibroblasts and The role of promoting the expression of the hyaluronan synthase gene is unknown or even suggested. [0003] prior art literature [0004] patent documents [0005] Patent Document 1: Japanese Patent Laid-Open No. 2010-95465 [0006] Patent Document 2: Japanese Patent Application Laid-Open No. 10-167972 [0007] Patent Document 3: Volume WO2014 / 199448 [0008] Patent Document 4: Book WO2008 / 018143 [0009] Patent Document 5: Book WO2004 / ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/747A61P17/00A61P19/02A61P43/00A61Q19/00C12N1/20A23L33/135A61K8/98A61K8/99A61K35/17A61K35/33
CPCA23L33/135A61K8/98A61K8/99A61K35/747A61P17/00A61P19/02A61P43/00A61Q19/00C12N1/20A23V2002/00C12N5/0656C12N2502/11C12N2502/70A23V2200/318A23V2200/3204A23V2200/324A23V2250/51A23V2400/169A23L33/30
Inventor 中井宽子广濑义隆室崎伸二
Owner เฮ้าส์ เวลล์เนสส์ ฟูดส์ คอร์ปอเรชั่น
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