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Process for preparing sophocarpine

A preparation process and a technology for sophocarpine, which are applied in the field of the preparation process of sophocarpine, can solve the problems of staying, unsuitable for industrial production and the like, and achieve the effects of high yield and high purity

Inactive Publication Date: 2003-06-18
宁夏药物研究所(有限公司)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Ningxia People's Publishing House publishes the book "Research and Utilization of Sophora Sophora" edited by Zhong Renshan, which discloses the method for preparing sophocarpine by column chromatography. However, these existing processes only stay in the laboratory and do not Suitable for industrial production

Method used

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  • Process for preparing sophocarpine
  • Process for preparing sophocarpine

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Experimental program
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Effect test

Embodiment 1

[0028] Total lye 125kg, alkalized with industrial NaOH to above PH12, benzene extraction 4-5 times, combined extracts, extracts and hydrochloric acid shift extraction, first extracted with 10kg of 5% hydrochloric acid, then with 10kg of 10% hydrochloric acid, and then with 10kg10 % Hydrochloric acid extraction, use thin layer chromatography to check that this part of the alkaloid is mainly sophocarpine. Through detection, if sophocarpine is in hydrochloric acid, the hydrochloric acid is adjusted to PH=9 with ARNaOH, crystals are precipitated, filtered, and dried to obtain crude sophocarpine. If it is detected that sophocarpine is in the extract, the extract is concentrated under reduced pressure to obtain 8 kg of crude sophocarpine. Recrystallized with ether to obtain 4.5 kg of sophocarpine.

Embodiment 2

[0030] 125kg of total lye, alkalized with industrial KOH to above PH12, extracted 4-5 times with chloroform, combined the extracts, and extracted with sulfuric acid by shifting, extracting with 10kg of 5% sulfuric acid, then with 10kg of 10% sulfuric acid, and then with 10kg10 % Sulfuric acid extraction, use thin-layer chromatography to check that this part of the alkaloid is mainly sophocarpine. Through detection, if sophocarpine is in sulfuric acid, the sulfuric acid is adjusted to PH=9.5 with ARNaOH, crystals are precipitated, filtered, and dried to obtain crude sophocarpine. If it is detected that sophocarpine is in the extract, the extract is concentrated under reduced pressure to obtain 8 kg of crude sophocarpine. Dissolve the crude sophocarpine in ethanol to make a hot saturated solution, stir and add 3 times the amount of cold water to precipitate white crystals, and then suction and filter to obtain 4.5 kg of sophocarpine.

Embodiment 3

[0032] 125kg of total lye, alkalized with industrial NaOH to above PH12, extracted 4-5 times with ether, combined the extracts, and extracted with phosphoric acid by shifting, extracting with 10kg of 5% phosphoric acid, then with 10kg of 10% phosphoric acid, and then with 10kg10 % Phosphoric acid extraction, use thin layer chromatography to check that this part of the alkaloid is mainly sophocarpine. Through testing, if sophocarpine is in phosphoric acid, the phosphoric acid is adjusted to PH=9.5 with ARNaOH, crystals are precipitated, filtered, and dried to obtain crude sophocarpine. If it is detected that sophocarpine is in the extract, the extract is concentrated under reduced pressure to obtain 8 kg of crude sophocarpine. Dissolve the crude sophocarpine in acetone to make a hot saturated solution, stir and add 4 times the amount of cold water to precipitate white crystals, and then suction and filter to obtain 4.5 kg of sophocarpine.

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Abstract

A process for preparing sophocarpine includes such steps as extracting from the solution of total alooerine with organic solvnet, displacement extracting with diluted acid, separating diluted acide to crystalyze, filtering and drying, or vacuume distilling of extract and recrystallizing. Its advantages are high yield and purity.

Description

Technical field [0001] The invention relates to the preparation of alkaloids, in particular to the preparation process of sophocarpine. Background technique [0002] Sophocarpine is one of the main alkaloids contained in the legume Sophora vulgaris. It is clinically used in the treatment of cancer patients and has a good effect. At the same time, it has antibacterial and anti-inflammatory effects. Ningxia People’s Publishing House published the book "Study and Utilization of Sophora Bean", edited by Zhong Renshan, and disclosed the method for preparing sophocarpine by column chromatography. However, these existing processes only stay in the laboratory. Suitable for industrial production. Summary of the invention [0003] The purpose of the present invention is to provide a preparation process of sophocarpine which is suitable for industrialized production, has high yield and high purity. [0004] In order to achieve the above objectives, the present invention adopts the followin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D471/22C07G5/00
Inventor 王忠效高斌黄建军王端宁
Owner 宁夏药物研究所(有限公司)
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