Dynamic brain function dual-mode imaging system based on fluorescence and photoacoustic tomography

Abstract

The invention discloses a dynamic brain function dual-mode imaging system based on fluorescence and photoacoustic tomography, which organically combines the two measurement methods of FMT / PAT, so thatthe source and probe of FMT and PAT are distributed on the same horizontal plane in order to avoid the difference in registration position of joint imaging, to achieve high sensitivity, high spatio-temporal resolution and full-brain range imaging dual-mode multi-parameter dynamic imaging of brain function and to take into account the high sensitivity of FMT in dynamics research and advantages ofPAT in high spatial resolution. PAT provides images of deep cerebral oxygen state related to nerve activity, including oxyhemoglobin concentration, deoxyhemoglobin concentration, blood oxygen saturation, etc. FMT provides fluorescence distribution images and kinetic parameter images, including fluorescence metabolism curves, permeability images, etc. The system has both high resolution of PAT andhigh sensitivity of FMT to realize imaging of cranial nerve activity.

Description

technical field [0001] The invention relates to the field of tissue optical molecular imaging, in particular to a dynamic imaging method for brain function, and in particular to a dynamic brain function dual-mode imaging system based on fluorescence and photoacoustic tomography. Background technique [0002] At present, based on long-term repeated clinical testing requirements, non-invasive brain functional imaging is an inevitable trend in the development of clinical brain functional medical imaging technology [1] . Remarkably, the main feature of brain activity is that even in a constant environment, the state of the brain is constantly changing and exhibits complex, multilevel processes. Observations on a single spatial or temporal scale are difficult to accurately predict and Understanding the Process of Brain Activity [2] . Therefore, the in vivo visualization of the dynamic function of the brain is of great significance for analyzing the working principle and operat...

AI Technical Summary

Problems solved by technology

[0018] The present invention aims to overcome the deficiencies of the existing methods, solve the problem that the existing single brain function dynamic imaging method cannot simultaneously satisfy high sensitivity, high temporal and spatial resolution, and whole-brain imaging, and develop a multi-parameter dual-mode integrated measurement mode Brain function dynamic imaging system to take into account the high sensitivity of FMT in dynamics research and the advantages of PAT in high spatial resolution

In addition, the present invention develops an integrated FMT / PAT joint imaging system to solve the problems that are not conducive to dynamic imaging, such as differences in registration positions caused by discrete measurements of multiple imaging methods, and long measurement time.

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