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Method for performing surface multi-hole modification of P4HB patch and P4HB patch

A porous surface and patch technology, applied in the field of biomedical materials, can solve problems such as deformation, poly-4-hydroxybutyrate patch dissolution, etc., achieve great clinical application value, reduce relative distribution concentration, and high surface porosity Effect

Active Publication Date: 2020-04-03
THE SIXTH AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the easy degradation and solubility of poly-4-hydroxybutyrate, it has been difficult to achieve porosity only on the surface of the poly-4-hydroxybutyrate patch itself while maintaining the shape or performance of the poly-4-hydroxybutyrate patch itself. The experimental conditions A little mishandling will cause the poly-4 hydroxybutyrate patch to dissolve or deform immediately

Method used

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  • Method for performing surface multi-hole modification of P4HB patch and P4HB patch
  • Method for performing surface multi-hole modification of P4HB patch and P4HB patch
  • Method for performing surface multi-hole modification of P4HB patch and P4HB patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～3

[0022] A poly-4 hydroxybutyrate patch with a porous surface, comprising a poly-4 hydroxybutyrate patch body and small holes on the mesh wire of the poly-4 hydroxybutyrate patch, the surface Porous poly-4 hydroxybutyrate patch is obtained by surface porosity modification of poly-4 hydroxybutyrate patch. The specific surface porosity modification method is as follows:

[0023] S1. Wash the medical or commercial poly-4-hydroxybutyrate patch with ethanol and deionized water, and dry it for later use;

[0024] S2. Mix dioxane and deionized water with a volume ratio of 3:2, add NaCl to prepare a NaCl saturated solution, and after fully stirring, soak the poly-4-hydroxybutyrate patch in the NaCl saturated solution for 30s, After 40s and 50s, take it out, wash it with water, and dry it at room temperature to obtain a poly-4-hydroxybutyrate patch with a porous surface.

Embodiment 4～6

[0026] A poly-4 hydroxybutyrate patch with a porous surface, comprising a poly-4 hydroxybutyrate patch body and small holes on the mesh wire of the poly-4 hydroxybutyrate patch, the surface Porous poly-4 hydroxybutyrate patch is obtained by surface porosity modification of poly-4 hydroxybutyrate patch. The specific surface porosity modification method is as follows:

[0027] S1. Wash the medical or commercial poly-4-hydroxybutyrate patch with ethanol and deionized water, and dry it for later use;

[0028] S2. Dioxane and deionized water with a volume ratio of 2:1 were mixed, and NaCl was added to prepare a NaCl saturated solution. After fully stirring, the poly-4-hydroxybutyrate patch was soaked in the NaCl saturated solution for 10s, After 20s and 30s, take it out, wash it with water, and dry it at room temperature to obtain a poly-4-hydroxybutyrate patch with a porous surface.

Embodiment 7～9

[0030] A poly-4 hydroxybutyrate patch with a porous surface, comprising a poly-4 hydroxybutyrate patch body and small holes on the mesh wire of the poly-4 hydroxybutyrate patch, the surface Porous poly-4 hydroxybutyrate patch is obtained by surface porosity modification of poly-4 hydroxybutyrate patch. The specific surface porosity modification method is as follows:

[0031] S1. Wash the medical or commercial poly-4-hydroxybutyrate patch with ethanol and deionized water, and dry it for later use;

[0032] S2. Mix dioxane and deionized water with a volume ratio of 1:1, add NaCl to prepare a saturated NaCl solution, and after stirring thoroughly, soak the poly-4-hydroxybutyrate patch in the saturated NaCl solution for 40s, 50s , 60s, take it out, wash it with water, and dry it at room temperature to obtain a poly-4-hydroxybutyrate patch with a porous surface.

[0033] The volume ratio of dioxane and deionized water used in Examples 1 to 9 and the soaking time of the poly-4 hydr...

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Abstract

The invention discloses a method for performing surface multi-hole modification of poly-4 hydroxybutyrate patch and a P4HB patch. The method for performing surface multi-hole modification of the P4HBpatch comprises the following steps of: S1, washing the poly-4 hydroxybutyrate patch with ethanol and deionized water, and baking the poly-4 hydroxybutyrate patch for standby application; and S2, mixing dioxane with deionized water, adding NaCl, preparing a NaCl saturated solution, performing sufficient stirring, soaking the poly-4 hydroxybutyrate patch in the NaCl saturated solution under a stirring state, taking out the soaked poly-4 hydroxybutyrate patch, washing the taken-out poly-4 hydroxybutyrate patch with water, and airing the washed poly-4 hydroxybutyrate patch at room temperature toobtain the surface multi-hole poly-4 hydroxybutyrate patch. The method for performing surface multi-hole modification disclosed by the invention is good in controllability, and simple and easy to operate, the prepared P4HB patch is high in surface hole forming rate, the hole diameter is 50nm-4[mu]m, the P4HB patch can have a medicine loading function, cell crawling is facilitated, the properties of the P4HB patch are further improved, and the method has enormous clinical application value.

Description

technical field [0001] The invention relates to the technical field of biomedical materials. Specifically, the invention relates to a method for modifying the surface of a P4HB patch to make porosity and the P4HB patch. Background technique [0002] Hernia is a common disease in general surgery. Its concept is that the tissues and organs in the normal cavity of the human body leave the normal anatomical position through the weak part of the human body, which can lead to changes in organ function, incarceration, ischemic necrosis and other complications. Timely and effective clinical intervention is an important means to prevent complications. In my country, the number of new hernia cases is not less than 3.5 million each year, and more than half of the patients need surgical treatment. At least 1.8 million pieces of hernia repair materials are needed in my country every year. At present, the clinical treatment for such diseases mainly adopts surgical operation for hernia me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/18C08J7/12C08L67/04
CPCA61L27/56A61L27/18C08J7/12C08J2367/04C08L67/04
Inventor 杨梓锋王辉李创坤过文泰曾展涛黄榕康王怀明胡民辉秦秀森张迪陈春吴小剑兰平汪建平
Owner THE SIXTH AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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