A high-throughput device and method for obtaining micro-tissue blocks
A tissue block and high-throughput technology, applied to sampling devices and other directions, can solve problems such as large errors and complicated operations
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Embodiment 1
[0042] refer to figure 1 , is a high-throughput device for obtaining micro-tissue blocks disclosed in this embodiment, including a sample table 1, sampling needles 2 distributed in an array, a flexible component that drives the sampling needle 2 to advance or retract, and a three-dimensional structure that drives the flexible component to move longitudinally. Translation stage 3.
[0043] The flexible component includes a cylinder 4 and a positioning part. The cylinder 4 is fixed on the side wall of the three-dimensional translation platform 3. The three-dimensional translation platform 3 drives the cylinder 4 to move longitudinally. The cylinder 4 is used to drive the sampling needle 2 to advance or retract.
[0044] The positioning part is the sliding table 5 that is clamped on the side wall of the cylinder 4, which is used to limit the rotation of the piston rod of the cylinder 4 when it is retracted. 5 realizes linear motion by clamping with the limit guide rail, the bott...
Embodiment 2
[0052] A high-throughput method for obtaining micro-tissue blocks disclosed in this embodiment includes the following steps:
[0053] refer to Figure 4 , take an array base plate, insert the sampling needles in an array distribution on the array base plate, and then use soldering glue to fix the sampling pins on the array base plate, the specific operation is as follows:
[0054] S101, take two mutually perpendicular optical glasses 14, U-shaped auxiliary orifice plate; the U-shaped auxiliary orifice plate includes a flat plate 15 and threaded pillars 16 located on both sides of the flat plate 15 and screwed into the flat plate 15, and place the flat plate 15 in it An upper surface of optical glass 14.
[0055] S102, rotate the threaded pillars 16 on both sides of the flat plate 15 to make the two threaded pillars 16 equal in height, take a pinhole array bottom plate 12, and place it on the upper surface of the two threaded pillars 16, so that the array bottom plate 12 is pa...
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