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Rapid high yielding purification process for neisseria meningitidis serogroup X capsular polysaccharide

A technology of Neisseria meningitidis and capsular polysaccharide is applied to medical preparations containing active ingredients, bacteria, multivalent vaccines, etc., to achieve the effect of rapid and efficient purification

Pending Publication Date: 2020-03-17
MSD WELLCOME TRUST HILLEMAN LAB PVT LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The purification process does not require any chromatographic steps

Method used

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  • Rapid high yielding purification process for neisseria meningitidis serogroup X capsular polysaccharide
  • Rapid high yielding purification process for neisseria meningitidis serogroup X capsular polysaccharide
  • Rapid high yielding purification process for neisseria meningitidis serogroup X capsular polysaccharide

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Embodiment Construction

[0034] The invention provides a process for quickly and efficiently purifying the capsular polysaccharide of serogroup X Neisseria meningitidis. The purified serogroup X N. meningitidis capsular polysaccharide obtained by the process of the present invention can be used to produce economical monovalent capsular polysaccharide or polysaccharide protein conjugate vaccine or multivalent combination vaccine and serogroup X meningitis Diagnostic tool for coccal infections.

[0035]The purification process provides purified serogroup X Neisseria meningitidis (also known as MenX) polysaccharide in a significantly reduced time. The purification process does not require any chromatographic steps.

[0036] The purification process of the present invention uses simple salts such as trisodium citrate and sodium sulfate at optimal concentrations. The crude polysaccharides in the fermentation broth are mixed with simple salts, added with organic solvents, centrifuged and ultrafiltered wit...

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Abstract

The present invention discloses a rapid high yielding purification process for Neisseria meningitidis serogroup X capsular polysaccharide. The capsular polysaccharide of present invention is capable of being used in the production of economical monovalent capsular polysaccharide or polysaccharide protein conjugate vaccine or multivalent combination vaccines as well as a diagnostic tool against meningococcal serogroup X infections. The process employs simple salts and lesser quantity of ethanol. The process is rapid, economic and scalable with high yield of purified polysaccharide of Neisseriameningitidis serogroup X.

Description

technical field [0001] The invention relates to a process for rapidly and efficiently purifying capsular polysaccharide of Neisseria meningitidis of serogroup X. The serogroup X Neisseria meningitidis bacterial capsular polysaccharide of the present invention can be used for the production of economical monovalent capsular polysaccharide or polysaccharide protein conjugate vaccine or multivalent combination vaccine as well as a diagnostic tool for serogroup X meningitis infection. Background technique [0002] Neisseria meningitidis (meningococcus or Men) is an aerobic, Gram-negative bacterium that has been serologically divided into major groups A, B, C, D, 29E, H, I, K, L , W135, X, Y and Z13 serogroups. This grouping system is based on the organism's capsular polysaccharides. [0003] The official website of WHO states that Neisseria meningitidis is one of the most common causes of bacterial meningitis worldwide, and it is the only bacterium capable of causing large-sca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P19/04A61K39/095C07K14/22C12N1/20C08B37/00
CPCA61K39/095C08B37/0003C12P19/04C12N1/20C08L5/00A61K2039/6031A61K2039/70G01N2333/22
Inventor 桑迪普·沙玛尼廷·库马尔萨麦德·哈尼夫达温德·吉尔
Owner MSD WELLCOME TRUST HILLEMAN LAB PVT LTD
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